129168-44-1

Upstream product

• 62936-33-8 ethyl 2-oxo-2-(4-phenoxyphenyl)acetate 
• 101-55-3 4-Bromodiphenyl ether 
• 79478-16-3 (4-Phenoxy)phenylglyoxylsaeure 

Downstream Products

• 1613439-82-9 N-(3-(N,N-dimethylaminocarbonylphenyl))-2-oxo-2-(4-phenoxyphenyl)acetamide 
• 1445604-02-3 2-(3-((R)-3-(3,4-dimethoxyphenyl)-1-((S)-1-(2-oxo-2-(4-phenoxy-phenyl)acetyl)piperidine-2-carbonyloxy)propyl)phenoxy)acetic acid 
• 1445604-11-4 C₄₃H₄₇NO₁₀ 
• 129168-40-7 N-Benzyl-2-hydroxy-2-(4-phenoxyphenyl)-propiohydroxamsaeure 
• 129168-39-4 2-Hydroxy-N-methyl-2-(4-phenoxyphenyl)propiohydroxamsaeure 
• 162405-23-4 N-(Ethoxymethoxy)-2-hydroxy-2-(4-phenoxyphenyl)-4-pentenamid 
• 162405-22-3 N-tert-Butoxy-2-cyclopropyl-2-hydroxy-2-(4-phenoxyphenyl)acetamid 
• 162405-24-5 N-(Ethoxymethoxy)-(4-phenoxyphenyl)glyoxylamid 
• 162405-25-6 N-tert-Butoxy-(4-phenoxyphenyl)glyoxylamid 
• 129168-28-1 N-Benzyl-(4-phenoxyphenyl)-glyoxylohydroxamsaeure 
• 129168-27-0 N-Methyl-4-phenoxy-phenylglyoxylohydroxamsaeure 

Relevant academic research and scientific papers

Cationic Ir/Me-BIPAM-catalyzed asymmetric intramolecular direct hydroarylation of α-ketoamides

Asymmetric intramolecular direct hydroarylation of α-ketoamides gives various types of optically active 3-substituted 3-hydroxy-2-oxindoles in high yields with complete regioselectivity and high enantioselectivities (84-98 % ee). This is realized by the use of the cationic iridium complex [Ir(cod) 2](BArF4) and the chiral O-linked bidentate phosphoramidite (R,R)-Me-BIPAM. Carbon's got a brand new bond: Asymmetric intramolecular direct hydroarylation of α-ketoamides gives various optically active 3-substituted 3-hydroxy-2-oxindoles in high yields with complete regioselectivity and high enantioselectivities. This is realized by the use of an asymmetric cationic iridium complex formed in situ (see Scheme).

Synthesis and properties of 3-alkylsubstituted 1-alkoxy(hydroxy)indolin-2-ones

N-alkoxy-2-aryl-2-hydroxycarboxamides 3 are smoothly converted into 3-alkylsubstituted 1-alkoxyindolin-2-ones (2A) by dicyclohexylcarbodiimide in boiling trichloroethene. The acidolysis of the 1-tert-butoxyindolin-2-ones 2Ab, g, i, k as well as the 1-alko