129171-47-7Relevant academic research and scientific papers
FATTY ACID DERIVATIVES AND THEIR USE
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Page/Page column 93; 96, (2019/01/21)
This disclosure concerns fatty acid derivatives, pharmaceutical compositions comprising the fatty acid derivatives, and methods of using the fatty acid derivatives, for example, to treat inflammation, chronic itch, chronic pain, an autoimmune disorder, atherosclerosis, a skin disorder, arthritis, a neurodegenerative disorder, or a psychiatric disorder in a subject. In some embodiments, the fatty acid derivative is a compound, or a stereoisomer, tautomer, or pharmaceutically acceptable salt thereof, having a structure according to: (I) wherein X is from 1-16 carbons in length, Z is aliphatic from 1-16 carbons in length, or is not present, Y is selected from: (II) R1, R2, and R3 are independently hydrogen or lower alkyl, R4 is lower alkyl, hydroxyl, carboxyl, or amine, R5 is hydrogen, lower alkyl, or halide, R6 is hydroxyl or substituted thiol, and each R7 is independently hydrogen or fluoride or is not present and the adjacent carbons form alkyne.
PRODUCTION METHOD OF 7-OCTENE-1,2,3-TRIOL
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Paragraph 0027, (2016/10/07)
PROBLEM TO BE SOLVED: To provide a method for producing 7-octene-1,2,3-triol which is useful as a polyolefin modifier or the like, industrially and easily at high yield in high purity. SOLUTION: A production method of 7-octene-1,2,3-triol has a step 1 for obtaining 2,3-epoxy-7-octene-1-ol by epoxidizing a carbon-carbon double bond on 2-position to 3-position of 2,7-octadiene-1-ol, and a step 2 for subjecting 2,3-epoxy-7-octene-1-ol obtained in the step 1 to hydration reaction. COPYRIGHT: (C)2016,JPOandINPIT
Preparation of oxocanes by electrophilic cyclizations of unsaturated alcohols in the presence of bis(collidine)halonium(I) hexafluorophosphates
Mendes, Christelle,Renard, Sylvie,Rofoo, Mazin,Roux, Marie-Claude,Rousseau, Gerard
, p. 463 - 471 (2007/10/03)
7-Octen-1-ols substituted in the sp3-sp3 carbon chain with carbocyclic (phenyl and cyclopropane) and heterocyclic (epoxide and dioxolane) moieties were prepared and their cyclizations in the presence of bis(collidine)iodonium(I) and-bromonium(I) hexafluorophosphates as electrophiles were studied. Oxocanes were obtained in modest to good yields when a rigid cyclic moiety (cyclopropane or phenyl) was present in the chain, while yields of cyclizations were lower if the cyclic component had a certain flexibility (dioxolane). Low yields were obtained with substrates bearing an epoxide substituent, probably because of stability problems due to the presence of collidine. With the vinylcyclopropane alcohol 12 we observed mainly the opening of the cyclopropane ring and the cyclization produced a tetrahydropyran derivative. Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003.
Isomer Selectivity in Stereocontrolled Payne Rearrangement-epoxide Cleavage of 2,3-Epoxy Alcohols in Aprotic Solvents: Application to an Enantioselective Total Synthesis of (+)-exo-Brevicomin
Page, Philip C. Bulman,Rayner, Christopher M.,Sutherland, Ian O.
, p. 1375 - 1382 (2007/10/02)
Organo-copper and -cuprate reagents may be used to trap the more reactive epoxy alkoxide isomer in a Lewis acid-catalysed Payne rearrangement process.This methodology has been used as the key step in a five-step enantioselective total synthesis of (+)-exo
PROSTANOIDS. VIII. PRODUCTION OF C7-SYNTHONS USED IN THE SYNTHESIS OF LEUCOTRIENES
Miftakhov, M. S.,Tolstikov, A. G.,Tolstikov, G. A.
, p. 618 - 622 (2007/10/02)
On the basis of the obtainable 2E,7-octadienol and its acetate and benzoate preparative methods were developed for the production of methyl 7-hydroxy-5S,6S-epoxyheptanoate and methyl 6-formyl-5S,6S-epoxyhexanoate, which are used as synthons for leucotrienes.
