129217-85-2Relevant articles and documents
Preparative synthesis via continuous flow of 4,4,5,5-tetramethyl-2-(3- trimethylsilyl-2-propynyl)-1,3,2-dioxaborolane: A general propargylation reagent
Fandrick, Daniel R.,Roschangar, Frank,Kim, Chunyoung,Hahm, Byoung J.,Cha, Myoung H.,Kim, Hyoun Y.,Yoo, Gyesang,Kim, Taeyun,Reeves, Jonathan T.,Song, Jinhua J.,Tan, Zhulin,Qu, Bo,Haddad, Nizar,Shen, Sherry,Grinberg, Nelu,Lee, Heewon,Yee, Nathan,Senanayake, Chris H.
, p. 1131 - 1140 (2012)
A scalable process for the preparation of 4,4,5,5-tetramethyl-2-(3- trimethylsilyl-2-propynyl)-1,3,2-dioxaborolane from trimethylsilylpropyne, isopropyl pinacol borate, and n-butyllithium is described. Problems associated with implementing a typical aqueous workup and batch process into production due to borolane ate equilibration and protonolysis are presented. To address these issues, a continuous-flow and distillation process was developed which efficiently produced 297 kg of the key propargylation reagent.
Divergent Synthesis and Real-Time Biological Annotation of Optically Active Tetrahydrocyclopenta[c]pyranone Derivatives
Nelson, Shawn D.,Wawer, Mathias J.,Nelson, Shawn D.,Schreiber, Stuart L.
, p. 6280 - 6283 (2016)
Sp3-rich compounds are underrepresented in libraries for probe- and drug-discovery, despite their promise of extending the range of accessible molecular shapes beyond planar geometries. With this in mind, a collection of single-enantiomer bicyclic, fused cyclopentenones underpinned by a complexity-generating Pauson-Khand cyclization was synthesized. A fingerprint of biological actions of these compounds was determined immediately after synthesis using real-time annotation?a process relying on multiplexed measurements of alterations in cell morphological features.
NHC-Cu-catalyzed addition of propargylboron reagents to phosphinoylimines. Enantioselective synthesis of trimethylsilyl-substituted homoallenylamides and application to the synthesis of S-(-)-cyclooroidin
Mszar, Nicholas W.,Haeffner, Fredrik,Hoveyda, Amir H.
supporting information, p. 3362 - 3365 (2014/03/21)
A catalytic method for the efficient and enantioselective addition of a 1-trimethylsilyl-substituted allene moiety to phosphinoylimines is presented. Transformations are promoted by 5.0 mol % of a copper complex of an N-heterocyclic carbene in the presenc
ANTIBACTERIAL AGENTS
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Page/Page column 82, (2013/12/03)
Antibacterial compounds of formula (I) are provided, as well as stereoisomers and pharmaceutically acceptable salts thereof; pharmaceutical compositions comprising such compounds; methods of treating bacterial infections by the administration of such compounds; and processes for the preparation of such compounds.
STEREOSELECTIVE SYNTHESIS OF CERTAIN TRIFLUOROMETHYL-SUBSTITUTED ALCOHOLS
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Page/Page column 13-14, (2010/12/29)
A process for synthesis of a compound of Formula (X) wherein R1 is an aryl group substituted with one to three substituent groups, wherein each substituent group of R1 is independently C1-C5 alkyl, aminocarbonyl, alkylaminocarbonyl, dialkylaminocarbonyl, halogen, carboxy, cyano, or trifluoromethyl, wherein each substituent group of R1 is optionally independently substituted with one to three substituents selected from C1-C3 alkyl, C1-C3 alkoxy, phenyl, and alkoxyphenyl; and R2 and R3 are each independently C1-C5 alkyl.
