129227-54-9

Upstream product

• 614-16-4 Benzoylacetonitrile 
• 52943-85-8 5-amino-3-methyl-4-nitroso-1-phenylpyrazole 
• 214914-34-8 1,6-diphenyl-3-methyl-1H-pyrazolo[3,4-b]pyrazine-5-carbonitrile 

Downstream Products

• 1593065-39-4 5-(5-amino-1,3,4-thiadiazol-2-yl)-1,6-diphenyl-3-methyl-1H-pyrazolo[3,4-b]pyrazine 
• 1593065-40-7 1,6-diphenyl-3-methyl-5-(6-phenylimidazo[2,1-b]-1,3,4-thiadiazol-2-yl)-1H-pyrazolo[3,4-b]pyrazine 
• 1380215-11-1 3-methyl-1-phenyl-1H-indeno[2,1-e]pyrazolo[3,4-b]pyrazin-5-one 
• 1430324-19-8 C₂₀H₁₅N₇S 
• 1430324-18-7 (Z)-2-(3-methyl-1-phenyindeno[2,1-e]pyrazolo[3,4-b]pyrazin-5(1H)-ylidene) hydrazinecarboxamide 
• 1430324-17-6 (Z)-3-methyl-1-phenylindeno[2,1-e]pyrazolo[3,4-b]pyrazin-5(1H)-one-oxime 
• 1430324-11-0 diethyl 2-(3-methyl-1-phenylindeno[2,1-e]pyrazolo[3,4-b]pyrazin-5(1H)-ylidene) malonate 
• 1430324-10-9 (Z)-2-(3-methyl-1-phenylindeno[2,1-e]pyrazolo[3,4-b]pyrazin-5(1H)-ylidene)-3-oxo-3-phenylpropanenitrile 
• 1430324-09-6 C₂₄H₁₇N₅O₂ 
• 1430324-08-5 (Z)-ethyl 2-(3-methyl-1-phenyl-1H,5H-indeno[2,1-e]pyrazolo[3,4-b]pyrazin-5(1H)-ylidene)oxobutanoate 
• 1430324-07-4 3-(methyl-1-phenylindeno[2,1-e]pyrazolo[3,4-b]pyrazin-5(1H)-ylidene)pentane-2,4-dione 
• 1430324-06-3 2-(3-methyl-1-phenylindeno[2,1-e]pyrazolo[3,4-b]pyrazin-5(1H)-ylidene) malononitrile 

Relevant academic research and scientific papers

Facile synthesis of some new pyrazolo [3,4-b] pyrazines and their antifungal activity

The synthesis of new pyrazolo [3,4-b] pyrazines and related heterocycles has been reported. The key intermediate 1,6-diphenyl-3-methyl-1H-pyrazolo[3,4-b]pyrazine-5- carbonitril 2 was obtained in one pot synthesis from the reaction of 5-amino-3-methyl-4-nitroso-1-phenylpyrazole 1 with benzoylacetonitrile. Modest antifungal activity was shown for some of the prepared compounds.

Anticancer and anti-inflammatory activities of some new pyrazolo[3,4-b]pyrazines

New derivatives of pyrazolo[3,4-b]pyrazines and related heterocycles were synthesized using 5-Amino-3-methyl-4-nitroso-1-phenyl-pyrazole (1) as a starting material. The 5-Acetyl derivative 15 was shown to be a useful key intermediate for the synthesis of several derivatives of pyrazolopyrazines. Some of the prepared compounds were evaluated for their anti-inflammatory and anti-breast cancer MCF-7 cell line activities. SAR study showed that compounds 15 and 29 exhibited remarkable anti-inflammatory activity, where 15 showed the same activity as that of the reference drug indomethacin. On the other hand, compounds 25i, 25j showed very significant inhibitory activity (p 0.001) against MCF-7 breast cancer cell line.

First synthesis and biological evaluation of indeno[2,1-e]pyrazolo[3,4-b] pyrazin-5-one and related derivatives

The synthesis of indeno[2,1-e]pyrazolo[3,4-b]pyrazin-5-one was achieved by intramolecular Friedel-Crafts reaction of the acid chloride 3-methyl-1,6- diphenyl-1H-pyrazolo[3,4-b] pyrazine-5-carboxylic acid chloride (4) using AlCl3 in boiling CS2. Compound 4 proved to be a versatile compound for the synthesis of several Indenopyrazolopyrazinone derivatives. The antibacterial and antifungal activities of selected derivatives were evaluated.