1292274-93-1

Basic information

• Product Name: 2-(4-trifluoromethoxy-phenyl)-2-aza-spiro[4.5]decane-1,8-dione
• Synonyms: 2-(4-trifluoromethoxy-phenyl)-2-aza-spiro[4.5]decane-1,8-dione
• CAS NO: 1292274-93-1
• Molecular Weight: 327.303
• Mol File: 1292274-93-1.mol

Chemical Properties

• CAS DataBase Reference: 2-(4-trifluoromethoxy-phenyl)-2-aza-spiro[4.5]decane-1,8-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-trifluoromethoxy-phenyl)-2-aza-spiro[4.5]decane-1,8-dione(1292274-93-1)
• EPA Substance Registry System: 2-(4-trifluoromethoxy-phenyl)-2-aza-spiro[4.5]decane-1,8-dione(1292274-93-1)

Safety Data

• Hazardous Substances Data: 1292274-93-1(Hazardous Substances Data)

Upstream product

• 1292274-40-8 (5α,8β)-8-hydroxy-2-(4-trifluoromethoxy-phenyl)-2-aza-spiro[4.5]decan-1-one 
• 1292278-44-4 ethyl 4-hydroxy-1-(2-methoxyethyl)cyclohexanecarboxylate 
• 1292278-43-3 1-(2-methoxy-ethyl)-4-oxo-cyclohexanecarboxylic acid ethyl ester 
• 17159-79-4 ethyl 4-oxocyclohexane-1-carboxylate 
• 1489-97-0 ethyl 1,4-dioxaspiro[4.5]decane-8-carboxylate 

Downstream Products

• 1292275-52-5 (5α,8α)-8-hydroxy-2-(4-trifluoromethoxy-phenyl)-8-trifluoromethyl-2-aza-spiro[4.5]decan-1-one 
• 1292275-53-6 (5α,8β)-8-hydroxy-2-(4-trifluoromethoxy-phenyl)-8-trifluoromethyl-2-aza-spiro[4.5]decan-1-one 
• 1292275-56-9 [(5α,8α)-8-hydroxy-1-oxo-2-(4-trifluoromethoxy-phenyl)-2-aza-spiro[4.5]dec-8-yl]-acetic acid ethyl ester 
• 1292278-68-2 [(5α,8β)-8-hydroxy-1-oxo-2-(4-trifluoromethoxy-phenyl)-2-aza-spiro[4.5]dec-8-yl]-acetic acid ethyl ester 
• 1292274-95-3 (5α,8α)-8-hydroxy-8-propyl-2-(4-trifluoromethoxy-phenyl)-2-aza-spiro[4.5]decan-1-one 
• 1292274-96-4 (5α,8β)-8-hydroxy-8-propyl-2-(4-trifluoromethoxy-phenyl)-2-aza-spiro[4.5]decan-1-one 
• 1292275-11-6 (5α,8α)-8-hydroxy-8-(3-methoxy-prop-1-ynyl)-2-(4-trifluoromethoxy-phenyl)-2-aza-spiro[4.5]decan-1-one 
• 1292275-12-7 (5α,8β)-8-hydroxy-8-(3-methoxy-prop-1-ynyl)-2-(4-trifluoromethoxy-phenyl)-2-aza-spiro[4.5]decan-1-one 
• 1292275-30-9 (5α,8α)-8-hydroxy-8-(3-methoxy-propyl)-2-(4-trifluoromethoxy-phenyl)-2-azaspiro[4.5]decan-1-one 
• 1292275-58-1 (5α,8α)-8-hydroxy-8-(2-hydroxyethyl)-2-(4-trifluoromethoxyphenyl)-2-azaspiro[4.5]decan-1-one 
• 1292278-91-1 [(5α,8α)-8-hydroxy-1-oxo-2-(4-trifluoromethoxy-phenyl)-2-aza-spiro[4.5]dec-8-yl]-acetic acid 
• 1292275-96-7 2-[(5α,8α)-8-hydroxy-1-oxo-2-(4-trifluoromethoxy-phenyl)-2-aza-spiro[4.5]dec-8-yl]-N,N-dimethyl-acetamide 
• 1292275-04-7 (5α,8α)-8-but-3-enyl-8-hydroxy-2-(4-trifluoromethoxy-phenyl)-2-aza-spiro[4.5]decan-1-one 
• 1292275-05-8 (5α,8β)-8-but-3-enyl-8-hydroxy-2-(4-trifluoromethoxy-phenyl)-2-aza-spiro[4.5]decan-1-one 

Relevant articles and documents

NEW HSL INHIBITORS USEFUL IN THE TREATMENT OF DIABETES

The present invention relates to compounds of formula (I) as well as pharmaceutically acceptable salts thereof. The are useful as HSL inhibitors and may, for example, be used in treatment of diabetes, metabolic syndrome, dyslipidemia, atherosclerosis, and obesity.

SPIRO-CONDENSED CYCLOHEXANE DERIVATIVES AS HSL INHIBITORS USEFUL FOR THE TREATMENT OF DIABETES

Compounds of formula (I) as well as pharmaceutically acceptable salts thereof can be used in the form of pharmaceutical compositions as HSL inhibitors for the treatment of diabetes, wherein R1,R2, R3, Ca and Cb have the significance given in claim 1.