1292286-17-9Relevant academic research and scientific papers
The discovery of potent and long-acting oral factor Xa inhibitors with tetrahydroisoquinoline and benzazepine P4 motifs
Watson, Nigel S.,Adams, Carl,Belton, David,Brown, David,Burns-Kurtis, Cynthia L.,Chaudry, Laiq,Chan, Chuen,Convery, Máire A.,Davies, David E.,Exall, Anne M.,Harling, John D.,Irvine, Stephanie,Irving, Wendy R.,Kleanthous, Savvas,McLay, Iain M.,Pateman, Anthony J.,Patikis, Angela N.,Roethke, Theresa J.,Senger, Stefan,Stelman, Gary J.,Toomey, John R.,West, Robert I.,Whittaker, Caroline,Zhou, Ping,Young, Robert J.
, p. 1588 - 1592 (2011/05/05)
The discovery and evaluation of potent and long-acting oral sulfonamidopyrrolidin-2-one factor Xa inhibitors with tetrahydroisoquinoline and benzazepine P4 motifs are described. Unexpected selectivity issues versus tissue plasminogen activator in the form
