1292289-97-4

Upstream product

• 6097-21-8 2-(4-nitrophenyl)-2-oxoethyl thiocyanate 
• 109-77-3 malononitrile 

Downstream Products

• 1396320-19-6 (E)-3-amino-3-dimethylamino-2-[4-(4-nitrophenyl)thiazol-2-yl]acrylonitrile 
• 1396320-23-2 (E)-3-amino-3-diethylamino-2-[4-(4-nitrophenyl)thiazol-2-yl]acrylonitrile 
• 1396320-18-5 (E)-3-amino-3-(4-methylpiperidin-1-yl)-2-[4-(4-nitrophenyl)thiazol-2-yl]acrylonitrile 
• 1396320-08-3 (E)-3-amino-3-morpholin-4-yl-2-[4-(4-nitrophenyl)thiazol-2-yl]acrylonitrile 
• 1396320-13-0 (E)-3-amino-2-[4-(4-nitrophenyl)thiazol-2-yl]-3-piperidin-1-yl-acrylonitrile 

Relevant academic research and scientific papers

Dimedone-catalyzed addition of amines into cyano group: Facile synthesis of thiazol-2-yl substituted E-acrylonitriles

An efficient dimedone-catalyzed synthesis of highly functionalized thiazol-2-yl substituted E-acrylonitrile derivatives has been established through two-step reaction of α-thiocyanate ketones with malononitrile and amines. The α-thiocyanate ketones were s