1292300-75-4

Basic information

• Product Name: TASP0415914
• Synonyms: TASP0415914;TSAP0415914
• CAS NO: 1292300-75-4
• Molecular Formula: C13H17N5O3S
• Molecular Weight: 323.37078
• Mol File: 1292300-75-4.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: TASP0415914(CAS DataBase Reference)
• NIST Chemistry Reference: TASP0415914(1292300-75-4)
• EPA Substance Registry System: TASP0415914(1292300-75-4)

Safety Data

• Hazardous Substances Data: 1292300-75-4(Hazardous Substances Data)

Usage

General Description

TASP0415914 is a chemical compound that belongs to the class of pyrimidine analogs. It is a potent and selective inhibitor of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase, an enzyme that is essential for the replication of the virus. TASP0415914 has shown promising anti-HIV-1 activity in preclinical studies and has the potential to be developed as a new therapeutic agent for the treatment of HIV infection. Its unique mechanism of action and high specificity make it a promising candidate for further development as an anti-HIV drug.

Upstream product

• 67899-00-7 2-amino-4-methyl-thiazole-5-carboxylic acid 
• 63788-62-5 2-(acetylamino)-4-methyl-1,3-thiazole-5-carboxylic acid 
• 85275-45-2 N-tert-butoxycarbonyl-3-piperidinol 
• 7210-76-6 ethyl-2-amino-4-methylthiazole-5-carboxylate 
• 89122-73-6 3-acetoxypiperidine 

Relevant articles and documents

Discovery of N-{5-[3-(3-hydroxypiperidin-1-yl)-1,2,4-oxadiazol-5-yl]-4- methyl-1,3-thiazol-2-yl}acetamide (TASP0415914) as an orally potent phosphoinositide 3-kinase γ inhibitor for the treatment of inflammatory diseases

Class I phosphoinositide 3-kinases (PI3Ks), particularly PI3Kγ, have become attractive drug targets for inflammatory and autoimmune disorders such as rheumatoid arthritis. Herein, we describe the synthesis and the structure-activity relationships (SAR) of a series of 2-amino-5-oxadiazolyl thiazoles, culminating in the identification of 8j (TASP0415914), an orally potent inhibitor of phosphoinositide 3-kinase γ (PI3Kγ). TASP0415914 demonstrated good potency in a cell-based assay and, furthermore, exhibited in vivo efficacy in a collagen induced arthritis (CIA) model in mice after oral administration.