1292324-44-7 Usage
Description
(S)-3-MethylaMino-tetrahydrofuran hydrochloride, also known as L-menthofuran hydrochloride, is a synthetic derivative of menthofuran with the molecular formula C5H11NO·HCl. It is a chiral building block in organic synthesis and pharmaceutical research, and has potential pharmacological properties as an anti-inflammatory and antimicrobial agent.
Uses
Used in Organic Synthesis:
(S)-3-MethylaMino-tetrahydrofuran hydrochloride is used as a chiral building block for the synthesis of various organic compounds, due to its unique structure and reactivity.
Used in Pharmaceutical Research:
(S)-3-MethylaMino-tetrahydrofuran hydrochloride is used as a key intermediate in the development of new pharmaceutical drugs, leveraging its chiral properties to create enantiomerically pure compounds with desired biological activities.
Used in Anti-inflammatory Applications:
(S)-3-MethylaMino-tetrahydrofuran hydrochloride is used as a potential anti-inflammatory agent, due to its ability to modulate inflammatory pathways and alleviate symptoms associated with inflammation.
Used in Antimicrobial Applications:
(S)-3-MethylaMino-tetrahydrofuran hydrochloride is used as a potential antimicrobial agent, exhibiting activity against various microorganisms and contributing to the development of new antimicrobial drugs.
Used in Drug Development:
(S)-3-MethylaMino-tetrahydrofuran hydrochloride is used in the development of new chemical entities, as its unique properties and reactivity can lead to the discovery of novel therapeutic agents with improved efficacy and selectivity.
Overall, (S)-3-MethylaMino-tetrahydrofuran hydrochloride has demonstrated diverse applications in the fields of chemistry and pharmacology, making it a valuable compound for research and development.
Check Digit Verification of cas no
The CAS Registry Mumber 1292324-44-7 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,9,2,3,2 and 4 respectively; the second part has 2 digits, 4 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 1292324-44:
(9*1)+(8*2)+(7*9)+(6*2)+(5*3)+(4*2)+(3*4)+(2*4)+(1*4)=147
147 % 10 = 7
So 1292324-44-7 is a valid CAS Registry Number.
1292324-44-7Relevant articles and documents
Discovery of a 5 H-benzo[4,5]cyclohepta[1,2-b ]pyridin-5-one (MK-2461) inhibitor of c-Met kinase for the treatment of cancer
Katz, Jason D.,Jewell, James P.,Guerin, David J.,Lim, Jongwon,Dinsmore, Christopher J.,Deshmukh, Sujal V.,Pan, Bo-Sheng,Marshall, C. Gary,Lu, Wei,Altman, Michael D.,Dahlberg, William K.,Davis, Lenora,Falcone, Danielle,Gabarda, Ana E.,Hang, Gaozhen,Hatch, Harold,Holmes, Rachael,Kunii, Kaiko,Lumb, Kevin J.,Lutterbach, Bart,Mathvink, Robert,Nazef, Naim,Patel, Sangita B.,Qu, Xianlu,Reilly, John F.,Rickert, Keith W.,Rosenstein, Craig,Soisson, Stephen M.,Spencer, Kerrie B.,Szewczak, Alexander A.,Walker, Deborah,Wang, Wenxian,Young, Jonathan,Zeng, Qinwen
supporting information; experimental part, p. 4092 - 4108 (2011/08/06)
c-Met is a transmembrane tyrosine kinase that mediates activation of several signaling pathways implicated in aggressive cancer phenotypes. In recent years, research into this area has highlighted c-Met as an attractive cancer drug target, triggering a number of approaches to disrupt aberrant c-Met signaling. Screening efforts identified a unique class of 5H-benzo[4,5] cyclohepta[1,2-b]pyridin-5-one kinase inhibitors, exemplified by 1. Subsequent SAR studies led to the development of 81 (MK-2461), a potent inhibitor of c-Met that was efficacious in preclinical animal models of tumor suppression. In addition, biochemical studies and X-ray analysis have revealed that this unique class of kinase inhibitors binds preferentially to the activated (phosphorylated) form of the kinase. This report details the development of 81 and provides a description of its unique biochemical properties.
