1292358-53-2Relevant academic research and scientific papers
Transition-Metal-Free Terminal Alkyne Addition to Isatins
Dhara, Kalyan,Kapat, Ajoy,Ghosh, Tridev,Dash, Jyotirmayee
, p. 4226 - 4268 (2016)
A 'direct' alkynylation of isatins, which uses potassium tert-butoxide to provide the desired 3-hydroxy-3-ethynyl-2-oxindoles in good to high yields, is reported. This protocol proceeds smoothly for both electron-rich and electron-deficient alkynes in com
Development of a novel octahedron rhodium complex and its application to the alkynylation of isatin derivatives
Wu, Ze-ying,Zhang, Zhen-wei,Ding, Lin-lin,Xiang, Mei,Luo, Shi-yi
supporting information, (2020/11/02)
A new octahedron rhodium complex was synthesized, which permits the direct activation of terminal alkynes and its reaction with isatin derivatives under an air atmosphere. An excellent yield (up to 99%) was obtained at a catalyst loading of 2 mol%.
Synthesis of 3-ethynyl-3-hydroxy-2-oxindoles and 3-hydroxy-3-(indol-3-yl) indolin-2-ones using CuWO4 nanoparticles as recyclable heterogeneous catalyst in aqueous medium
Paplal, Banoth,Sathish, Kota,Nagaraju, Sakkani,Kashinath, Dhurke
, (2019/11/14)
A simple method for the direct activation of phenyl acetylenes (spC-H activation) and selective synthesis of 3-hydroxy-3-(indol-3-yl) indolin-2-ones and 3,3′-bis(indolyl)indolin-2-ones (via Friedel-Crafts alkylation reaction) is reported in presence of Cu
Light-Stable Silver N-Heterocyclic Carbene Catalysts for the Alkynylation of Ketones in Air
Lazreg, Fama,Lesieur, Mathieu,Samson, Andrew J.,Cazin, Catherine S. J.
, p. 209 - 213 (2016/01/25)
N-Heterocyclic carbene (NHC) silver(I) complexes were employed efficiently in the alkynylation of ketones. These cationic complexes were highly active and efficient under mild conditions and in air without the need for an additive. The mechanism of this transformation was investigated. Experiments suggest that the formation of a silver acetylide key intermediate and the release of one ligand from the silver centre enable the transformation.
Catalytic C-H activation of arylacetylenes: A fast assembly of 3-(arylethynyl)-3-hydroxyindolin-2-ones using CuI/DBU
Chouhan, Mangilal,Senwar, Kishna Ram,Kumar, Kapil,Sharma, Ratnesh,Nair, Vipin A.
, p. 195 - 202 (2014/03/21)
A highly efficient and atom-economic methodology has been developed for the synthesis of 3-(arylethynyl)-3-hydroxyindolin-2-ones from isatins by C-H activation of arylacetylenes using a catalytic quantity of copper(I) iodide (5 mol%) and DBU (20 mol%) at 25°C, affording the products in excellent yields in very short reaction time (5 min).
"On water"-promoted direct alkynylation of isatins catalyzed by NHC-silver complexes for the efficient synthesis of 3-hydroxy-3-ethynylindolin- 2-ones
Fu, Xiao-Pu,Liu, Li,Wang, Dong,Chen, Yong-Jun,Li, Chao-Jun
supporting information; experimental part, p. 549 - 553 (2011/05/03)
The direct alkynylation of isatins catalyzed by NHC-Ag complexes via the activation of alkyne C-H bond on water was developed for the efficient synthesis of 3-hydroxy-3-ethynylindolin-2-ones under an air atmosphere. A remarkable rate-enhancement by water
