129243-56-7Relevant articles and documents
Synthesis of Heteroaromatic Thyrotropin-releasing Hormone Analogues
Bladon, Christine M.
, p. 1151 - 1158 (2007/10/02)
Novel thyrotropin-releasing hormone (TRH) analogues containing the unnatural and heteroaromatic L-pyrrolylalanine, D-pyrrolylalanine, and L-furylalanine amino acids in position 2 have been synthesised.L-Furylalanine was obtained by the stereospecific hydrolysis of the N-acetyl-D,L-amino acid with acylase I.A protected derivative of D,L-pyrrolylalanine was prepared, the racemate was incorporated into the tripeptide and the LLL and LDL diastereoisomers were separated at the end of the synthesis.