129247-05-8

Basic information

• Product Name: 3-Chloro-7-methyl-2-phenyl-indolizine-1-carboxylic acid methyl ester
• CAS NO: 129247-05-8
• Molecular Weight: 299.757
• Mol File: 129247-05-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-Chloro-7-methyl-2-phenyl-indolizine-1-carboxylic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Chloro-7-methyl-2-phenyl-indolizine-1-carboxylic acid methyl ester(129247-05-8)
• EPA Substance Registry System: 3-Chloro-7-methyl-2-phenyl-indolizine-1-carboxylic acid methyl ester(129247-05-8)

Safety Data

• Hazardous Substances Data: 129247-05-8(Hazardous Substances Data)

Upstream product

• 108-89-4 picoline 
• 650-51-1 sodium trichloroacetate 
• 4891-38-7 phenylpropynoic acid methyl ester 
• 103-26-4 methyl cinnamate 

Relevant articles and documents

1,3-DIPOLAR CYCLOADDITION REACTIONS OF YLIDES FORMED FROM PYRIDINES AND DICHLOROCARBENE

Pyridinium dichloromethylides, generated from substituted pyridines and dichlorocarbene, react endo-stereoselectively with dimethyl maleate to give substituted 3,3-dichloro-1,2,3,8a-tetrahydroindolizine-1,2-dicarboxylic acid dimethyl esters; the latter compounds are readily dehydrochlorinated and dehydrogenated to give the corresponding indolizine derivatives.Reaction of 3-substituted pyridines with dichlorocarbene and dimethyl maleate leads predominantly to the formation of 8-substituted indolizines.Cycloaddition of 4-picolinium dichloromethylide to unsymmetrical dipol arophiles occurs regioselectively.The observed selectivity in these reactions is consistent with predictions made on the basis of PMO theory.