129254-75-7

Usage

Uses

Used in Pharmaceutical Industry:
1-(3-BROMO-PROPYL)-2-FLUORO-BENZENE is used as a key intermediate in the synthesis of various pharmaceuticals. Its unique halogenated structure allows for the development of new drugs with specific therapeutic properties, contributing to the advancement of medicinal chemistry.
Used in Agrochemical Industry:
In the agrochemical sector, 1-(3-BROMO-PROPYL)-2-FLUORO-BENZENE serves as an essential building block for the creation of novel agrochemicals. Its incorporation into these compounds can enhance their effectiveness in pest control and crop protection, thereby supporting sustainable agriculture.
Used in Organic Compounds Synthesis:
1-(3-BROMO-PROPYL)-2-FLUORO-BENZENE is utilized as a versatile intermediate for the synthesis of a wide range of organic compounds. Its reactivity and structural features make it suitable for the production of various specialty chemicals used across different industries.
Used in Polymer and Resin Production:
This halogenated aromatic compound is also employed as a building block in the production of polymers and resins. The incorporation of 1-(3-BROMO-PROPYL)-2-FLUORO-BENZENE into these materials can impart specific properties, such as flame retardancy or enhanced durability, broadening their applications in various end-use markets.

Upstream product

• 76727-24-7 3-(2-fluorophenyl)propan-1-ol 
• 446-52-6 2-Fluorobenzaldehyde 
• 104201-65-2 methyl (2E)-3-(2-fluorophenyl)prop-2-enoate 
• 143654-59-5 methyl 3-(2-fluorophenyl)propanoate 
• 637-59-2 1-Bromo-3-phenylpropane 
• 1643-26-1 3-(2-fluorophenyl)propionic acid 

Downstream Products

• 86373-33-3 4-[3-(2-Fluoro-phenyl)-propylamino]-benzoic acid ethyl ester 
• 333782-49-3 methyl (3R,4R)-4-[3-(6-methoxyquinolin-4-yl)propyl]-1-[3-(2-fluorophenyl)propyl]piperidine-3-carboxylate 
• 129255-14-7 1-(2-fluorophenyl)-4-(pyridin-4-yl)butane 
• 129255-15-8 1-(2-fluorophenyl)-4-(pyridin-4-yl)-pentane 
• 1093172-53-2 [5-(2-{4-[3-(2-fluorophenyl)propoxy]-3-trifluoromethylphenyl}ethyl)-2,2-dimethyl-1,3-dioxan-5-yl]carbamic acid t-butyl ester 
• 86373-34-4 4-[3-(2-Fluoro-phenyl)-propylamino]-benzoic acid 

Relevant academic research and scientific papers

Remote migratory cross-electrophile coupling and olefin hydroarylation reactions enabled by in situ generation of nih

A highly efficient strategy for remote reductive cross-electrophile coupling has been developed through the ligand-controlled nickel migration/arylation. This general protocol allows the use of abundant and bench-stable alkyl bromides and aryl bromides for the synthesis of a wide range of structurally diverse 1, 1-diarylalkanes in excellent yields and high regioselectivities under mild conditions. We also demonstrated that alkyl bromide could be replaced by the proposed olefin intermediate while using n-propyl bromide/Mn0 as a potential hydride source.

DIRECT PALLADIUM-CATALYZED AROMATIC FLUORINATION

Provided herein are palladium complexes comprising a ligand of Formula (Α') and a ligand of Formula (B), wherein R1-R18 are as defined herein. The palladium complexes are useful in methods of fluorinating aryl and heteroaryl substrates. Further provided are compositions and kits comprising the palladium complexes.

AMINE COMPOUND AND PHARMACEUTICAL USE THEREOF

Provided is a novel amine compound represented by the following formula (I) having a superior peripheral blood lymphocyte decreasing action and superior in the immunosuppressive action, rejection suppressive action and the like, which shows decreased side effects of, for example, bradycardia and the like, or a pharmaceutically acceptable acid addition salt thereof, or a hydrate thereof, or a solvate thereof. wherein each symbol is as defined in the specification.

Synthesis of N-glyoxyl prolyl and pipecolyl amides and thioesters and evaluation of their in vitro and in vivo nerve regenerative effects

The recent discovery that small molecule ligands for the peptidyl-prolyl isomerase (PPIase) FKBP12 possess powerful neuroprotective and neuroregenerative properties in vitro and in vivo suggests therapeutic utility for such compounds in neurodegenerative disease. The neurotrophic effects of these compounds are independent of the immunosuppressive pathways by which drugs such as FK506 and rapamycin operate. Previous work by ourselves and other groups exploring the structure-activity relationships (SAR) of small molecules that mimic only the FKBP binding domain portion of FK506 has focused on esters of proline and pipecolic acid. We have explored amide and thioester analogues of these earlier structures and found that they too are extremely potent in promoting recovery of lesioned dopaminergic pathways in a mouse model of Parkinson's disease. Several compounds were shown to be highly effective upon oral administration after lesioning of the dopaminergic pathway, providing further evidence of the potential clinical utility of a variety of structural classes of FKBP12 ligands.