129255-95-4Relevant academic research and scientific papers
Structural Tuning and Conformational Stability of Aromatic Oligoamide Foldamers
Annala, Riia,Suhonen, Aku,Laakkonen, Heikki,Permi, Perttu,Nissinen, Maija
, p. 16671 - 16680 (2017)
A series of aromatic oligoamide foldamers with two or three pyridine-2,6-dicarboxamide units as their main folding motifs and varying aromatic building blocks as linkers have been synthetized to study the effects of the structural variation on the folding properties and conformational stability. Crystallographic studies showed that in the solid state the central linker unit either elongates the helices and more open S-shaped conformations, compresses the helices to more compact conformations, or acts as a rigid spacer separating the pyridine-2,6-dicarboxamide units, which for their part add the predictability of the conformational properties. Multidimensional NMR studies showed that, even in solution, foldamers show conformational stability and folded conformations comparable to the solid-state structures.
