1292797-89-7

Upstream product

• 59768-74-0 (S)-2-t-butoxycarbonylaminosuccinic acid 4-methyl ester 
• 16652-76-9 L-valine benzyl ester p-toluenesulfonate salt 
• 3392-09-4 Boc-Leu-ONSu 
• 1292797-85-3 C₂HF₃O₂*C₁₇H₂₄N₂O₅ 
• 1292797-86-4 C₂₂H₃₂N₂O₇ 

Downstream Products

• 1355027-61-0 N-[(4-{[(2,6-dimethylphenyl)carbamoyl]amino}phenyl)acetyl]-L-leucyl-L-α-aspartyl-N-(12-aminododecyl)-L-valinamide trifluoroacetate 
• 1372701-03-5 C₄₀H₅₁N₅O₈ 
• 1355027-72-3 (2S)-2-{[(2S)-2-{[(2S)-2-{[(4-{[(2,6-dimethylphenyl)carbamoyl]amino}phenyl)acetyl]amino}-4-methylpentanoyl]amino}-4-methoxy-4-oxobutanoyl]amino}-3-methylbutanoic acid 
• 1372701-06-8 methyl (3S)-3-{[(2S)-2-{[(4-{[(2,6-dimethylphenyl)carbamoyl]amino}phenyl)acetyl]amino}-4-methylpentanoyl]amino}-4-({(2S)-3-methyl-1-oxo-1-[(2-phenylethyl)amino]butan-2-yl}amino)-4-oxobutanoate 
• 1355027-59-6 N-[(4-{[(2,6-dimethylphenyl)carbamoyl]amino}phenyl)acetyl]-L-leucyl-L-α-aspartyl-N-(2-phenylethyl)-L-valinamide 
• 1355027-73-4 methyl (20S,23S)-23-{[(2S)-2-{[(4-{[(2,6-dimethylphenyl)carbamoyl]amino}phenyl) acetyl]amino}-4-methylpentanoyl]amino}-2,2-dimethyl-4,19,22-trioxo-20-(propan-2-yl)-3-oxa-5,18,21-triazapentacosan-25-oate 
• 1355027-74-5 N-[(4-{[(2,6-dimethylphenyl)carbamoyl]amino}phenyl)acetyl]-L-leucyl-L-α-aspartyl-N-{12-[(tert-butoxycarbonyl)amino]dodecyl}-L-valinamide 
• 1292797-88-6 C₂HF₃O₂*C₂₃H₃₅N₃O₆ 

Relevant academic research and scientific papers

LDV peptidomimetics equipped with biotinylated spacer-arms: Synthesis and biological evaluation on CCRF-CEM cell line

The tripeptide Leu-Asp-Val (LDV) is known to bind α4β 1 integrin in leukemia cells. Here we have synthesized a LDV peptidomimetic equipped with a biotin-conjugated spacer-arm. Compound 9 acts as an inhibitor of the α4β1 integrin in an adhesion assay using fluorescently labeled, α4β 1 integrin-expressing leukemia CCRF-CEM cells. Furthermore, when bound to neutravidin-coated plates, compound 9 could capture CCRF-CEM cells. Such biotin-conjugated LDV peptidomimetic may thus represent a novel tool for biotechnological applications using avidin interaction for leukapheresis or leukemia cell targeting.