1292808-47-9Relevant academic research and scientific papers
C20-trifluoro-5-oxo-ETE: A metabolically stable 5-oxo-ETE derivative
Patel, Pranav,Gore, Vivek,Powell, William S.,Rokach, Joshua
, p. 1987 - 1990 (2011)
The total synthesis of C20-trifluoro-6(E),8(Z),11(Z),14(Z) 5-oxo-ETE is reported. This compound was designed as an ω-oxidation- resistant analog of 5-oxo-ETE that would be resistant to metabolism. The trifluoro derivative of 5-oxo-ETE stimulated calcium mobilization in neutrophils and desensitized these cells to subsequent exposure to 5-oxo-ETE.
