1292810-84-4Relevant articles and documents
Disubstituted bis-THF moieties as new P2 ligands in nonpeptidal HIV-1 protease inhibitors
Hohlfeld, Konrad,Tomassi, Cyrille,Wegner, Joerg Kurt,Kesteleyn, Bart,Linclau, Bruno
, p. 461 - 465 (2011/08/22)
A series of darunavir analogues featuring a substituted bis-THF ring as P2 ligand have been synthesized and evaluated. High affinity protease inhibitors (PIs) with an interesting activity on wild-type HIV and a panel of multi-PI resistant HIV-1 mutants co