129287-00-9Relevant academic research and scientific papers
One-Pot Synthesis of Polyfunctionally Substituted 2,3-Dihydrothiazoles and Thiazolidinones
Mohareb, Rafat M.,Sherif, Sherif M.,Abdel-Aal, Fatma A. M.,Sayed, Nadia I. A.
, p. 1143 - 1146 (2007/10/02)
The reaction of phenyl isothiocyanate with the active methylene reagents 1a-e gives the nonisolable 1:1 adducts 2a-e.The latter react with α-halogenated compounds, e. g. phenacyl bromide, bromoacetyl bromide, chloroacetone, chloroacetonitrile and some hydrazonoyl halides to give the corresponding polyfunctionally substituted 2,3-dihydrothiazoles or thiazolidinone ring system.
