129287-52-1Relevant academic research and scientific papers
(E,R,R)-5-Alkylidene-2-tert-butyl-6-methyl-1,3-dioxan-4-ones: Preparation from (R)-3-Hydroxybutbutyric Acid, Cuprate Additions and Hydrolyses to 3-Hydroxycarboxylic Acids with Chiral Secondary Alkyl Substituents in the 2-Position
Amberg, Willi,Seebach, Dieter
, p. 2413 - 2428 (2007/10/02)
Li enolates of (R,R)-2-tert-Butyl-6-methyl-1,3-dioxan-4-one add to aliphatic or aromatic aldehydes with relative topicity Re,Re (2:1 to 10:1, 9 examples).The title compounds are obtained from these aldol adducts by dehydration through mesylates (5 example
(2R)-5-Alkyl-2-tert-butyl-6-methyl-4H-1,3-dioxin-4-ones as Intermediates for the Preparation of α,β,β-Trisubstituted β-Hydroxycarboxylic Acids from (R)-3-Hydroxybutyric Acid under Self-Regeneration of the Stereogenic Center
Amberg, Willi,Seebach, Dieter
, p. 2429 - 2438 (2007/10/02)
The exocyclic double bonds of the readily available (2R,6R)-5-alkylidene-2-tert-butyl-6-methyl-1,3-dioxan-4-ones (preceding paper) are shifted to the endocyclic position by treatment with Pd-C/H2 to give the dioxins 2-6 in overall yields of 40-60percent (
