129287-66-7Relevant academic research and scientific papers
Alkylations of (R,R)-2-t-Butyl-6-methyl-1,3-dioxan-4-ones which are not Possible with Lithium Amides may be Achieved with a Schwesinger P4 Base
Pietzonka, Thomas,Seebach, Dieter
, p. 1837 - 1843 (2007/10/02)
Enolates A of the dioxanones specified in the title, when generated with lithium amide bases, can only be alkylated with highly reactive electrophiles, and only once.With Schwesinger's t-Bu-P4 base (a very strong, so-called neutral base, containing 4P and
(E,R,R)-5-Alkylidene-2-tert-butyl-6-methyl-1,3-dioxan-4-ones: Preparation from (R)-3-Hydroxybutbutyric Acid, Cuprate Additions and Hydrolyses to 3-Hydroxycarboxylic Acids with Chiral Secondary Alkyl Substituents in the 2-Position
Amberg, Willi,Seebach, Dieter
, p. 2413 - 2428 (2007/10/02)
Li enolates of (R,R)-2-tert-Butyl-6-methyl-1,3-dioxan-4-one add to aliphatic or aromatic aldehydes with relative topicity Re,Re (2:1 to 10:1, 9 examples).The title compounds are obtained from these aldol adducts by dehydration through mesylates (5 example
