129295-31-4 Usage
Uses
Used in Pharmaceutical Industry:
6-CHLORO-1H-INDAZOLE-3-CARBOXYLIC ACID is used as a key intermediate in the synthesis of various pharmaceuticals for its ability to contribute to the development of biologically active molecules. Its carboxylic acid group and chlorine atom facilitate the formation of diverse chemical structures, which can be further modified to create new drugs with specific therapeutic effects.
Used in Agrochemical Industry:
In the agrochemical sector, 6-CHLORO-1H-INDAZOLE-3-CARBOXYLIC ACID is utilized as a precursor in the production of agrochemicals, such as pesticides and herbicides. Its structural features allow for the creation of compounds that can effectively target and control pests and weeds, thereby enhancing crop protection and yield.
Used in Research and Development:
6-CHLORO-1H-INDAZOLE-3-CARBOXYLIC ACID is employed as a research compound for exploring its potential pharmacological properties. It serves as a starting material for the design and synthesis of new drug candidates, particularly in the fields of medicinal chemistry and drug discovery. Its unique structure and functional groups make it a versatile building block for the development of innovative therapeutic agents.
Check Digit Verification of cas no
The CAS Registry Mumber 129295-31-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,9,2,9 and 5 respectively; the second part has 2 digits, 3 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 129295-31:
(8*1)+(7*2)+(6*9)+(5*2)+(4*9)+(3*5)+(2*3)+(1*1)=144
144 % 10 = 4
So 129295-31-4 is a valid CAS Registry Number.
InChI:InChI=1/C8H5ClN2O2/c9-4-1-2-5-6(3-4)10-11-7(5)8(12)13/h1-3H,(H,10,11)(H,12,13)
129295-31-4Relevant academic research and scientific papers
Development of potent serotonin-3 (5-HT3) receptor antagonists. II. Structure-activity relationships of N-(1-benzyl-4-methylhexahydro-1H-1,4- diazepin-6-yl)carboxamides
Harada,Morie,Hirokawa,Terauchi,Fujiwara,Yoshida,Kato
, p. 1912 - 1930 (2007/10/03)
Our studies on 4-amino-5-chloro-2-ethoxybenzamides led to the discovery that the N-(1,4-dimethylhexahydro-1H-1,4-diazepin-6-yl)benzamide 9 and the 1- benzyl-4-methylhexahydro-1H-1,4-diazepine analogue 10 are potent serotonin-3 (5-HT3) receptor antagonists. Structure-activity relationship (SAR) studies on the influence of the aromatic nucleus of 9 and 10 upon inhibition of the von Bezold-Jarisch reflex in rats are described. Heteroaromatic rings such as pyrrole, thiophene, furan, pyridine, pyridaziae, 1,2-benzisoxazole, indole, quinoline, and isoquinoline rings showed weak 5-HT3 receptor antagonistic activity. Within this series, use of the 1H-indazole ring as an aromatic moiety led to a substantial increase of the activity; the 1H- indazolylcarboxamides 54, 57, 97, and 102 showed potent 5-HT3 receptor antagonistic activity. The optimal compound identified via extensive SAR studies was N-(1-benzyl-4-methylhexahydro-1H-1,4-diazepin-6-yl)-1H-indazole- 3-carboxamide (54), whose effect was superior to that of the corresponding benzamide 10 and essentially equipotent to those of ondansetron (1) and granisetron (4).
