129295-32-5

Basic information

• Product Name: 7-CHLORO-1H-INDAZOLE-3-CARBOXYLIC ACID
• Synonyms: 7-CHLORO-1H-INDAZOLE-3-CARBOXYLIC ACID;7-CHLORO-3-(1H)INDAZOLE CARBOXYLIC ACID;7-Chloroindazole-3-carboxylic acid;7-chloro-3-(1H)-indazole;7-Chloro-3-(1H)-indazolecarobxylicacid;1H-Indazole-3-carboxylic acid, 7-chloro-
• CAS NO: 129295-32-5
• Molecular Formula: C8H5ClN2O2
• Molecular Weight: 196.59
• Product Categories: Heterocycles series;Indole;API intermediates;Indazoles
• Mol File: 129295-32-5.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 270.838°C at 760 mmHg
• Flash Point: 117.599°C
• Appearance: /
• Density: 1.644g/cm³
• Vapor Pressure: 0.003mmHg at 25°C
• Refractive Index: 1.744
• Storage Temp.: 2-8°C
• PKA: 2.63±0.10(Predicted)
• CAS DataBase Reference: 7-CHLORO-1H-INDAZOLE-3-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 7-CHLORO-1H-INDAZOLE-3-CARBOXYLIC ACID(129295-32-5)
• EPA Substance Registry System: 7-CHLORO-1H-INDAZOLE-3-CARBOXYLIC ACID(129295-32-5)

Safety Data

• Hazardous Substances Data: 129295-32-5(Hazardous Substances Data)

Usage

General Description

7-Chloro-1H-indazole-3-carboxylic acid is a chemical compound that belongs to the class of organic compounds known as indazoles, which are aromatic heterocyclic compounds containing a pyrazole ring fused to a benzene ring. This specific compound is characterized by the presence of a chlorine atom attached to the seventh carbon atom of the indazole ring, and a carboxylic acid functional group attached to the third carbon atom of the indazole ring. It can be synthesized in the laboratory, though its specific uses are contingent on its further modification and derivatization. As of now, there isn't much information available about its toxicity, environmental impact, or potential for commercial application.

InChI:InChI=1/C8H5ClN2O2/c9-5-3-1-2-4-6(5)10-11-7(4)8(12)13/h1-3H,(H,10,11)(H,12,13)

Upstream product

• 7477-63-6 7-chloroisatin 

Relevant articles and documents

Development of potent serotonin-3 (5-HT3) receptor antagonists. II. Structure-activity relationships of N-(1-benzyl-4-methylhexahydro-1H-1,4- diazepin-6-yl)carboxamides

Our studies on 4-amino-5-chloro-2-ethoxybenzamides led to the discovery that the N-(1,4-dimethylhexahydro-1H-1,4-diazepin-6-yl)benzamide 9 and the 1- benzyl-4-methylhexahydro-1H-1,4-diazepine analogue 10 are potent serotonin-3 (5-HT3) receptor antagonists. Structure-activity relationship (SAR) studies on the influence of the aromatic nucleus of 9 and 10 upon inhibition of the von Bezold-Jarisch reflex in rats are described. Heteroaromatic rings such as pyrrole, thiophene, furan, pyridine, pyridaziae, 1,2-benzisoxazole, indole, quinoline, and isoquinoline rings showed weak 5-HT3 receptor antagonistic activity. Within this series, use of the 1H-indazole ring as an aromatic moiety led to a substantial increase of the activity; the 1H- indazolylcarboxamides 54, 57, 97, and 102 showed potent 5-HT3 receptor antagonistic activity. The optimal compound identified via extensive SAR studies was N-(1-benzyl-4-methylhexahydro-1H-1,4-diazepin-6-yl)-1H-indazole- 3-carboxamide (54), whose effect was superior to that of the corresponding benzamide 10 and essentially equipotent to those of ondansetron (1) and granisetron (4).