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129295-32-5

7-Chloro-1H-indazole-3-carboxylic acid is a chemical compound belonging to the class of organic compounds known as indazoles, which are aromatic heterocyclic compounds containing a pyrazole ring fused to a benzene ring. This specific compound is characterized by the presence of a chlorine atom attached to the seventh carbon atom of the indazole ring, and a carboxylic acid functional group attached to the third carbon atom of the indazole ring. It can be synthesized in the laboratory, though its specific uses are contingent on its further modification and derivatization. As of now, there isn't much information available about its toxicity, environmental impact, or potential for commercial application.

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  • 129295-32-5 Structure

  • Basic information

    1. Product Name: 7-CHLORO-1H-INDAZOLE-3-CARBOXYLIC ACID
    2. Synonyms: 7-CHLORO-1H-INDAZOLE-3-CARBOXYLIC ACID;7-CHLORO-3-(1H)INDAZOLE CARBOXYLIC ACID;7-Chloroindazole-3-carboxylic acid;7-chloro-3-(1H)-indazole;7-Chloro-3-(1H)-indazolecarobxylicacid;1H-Indazole-3-carboxylic acid, 7-chloro-
    3. CAS NO:129295-32-5
    4. Molecular Formula: C8H5ClN2O2
    5. Molecular Weight: 196.59
    6. EINECS: N/A
    7. Product Categories: Heterocycles series;Indole;API intermediates;Indazoles
    8. Mol File: 129295-32-5.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 270.838°C at 760 mmHg
    3. Flash Point: 117.599°C
    4. Appearance: /
    5. Density: 1.644g/cm3
    6. Vapor Pressure: 0.003mmHg at 25°C
    7. Refractive Index: 1.744
    8. Storage Temp.: 2-8°C
    9. Solubility: N/A
    10. PKA: 2.63±0.10(Predicted)
    11. CAS DataBase Reference: 7-CHLORO-1H-INDAZOLE-3-CARBOXYLIC ACID(CAS DataBase Reference)
    12. NIST Chemistry Reference: 7-CHLORO-1H-INDAZOLE-3-CARBOXYLIC ACID(129295-32-5)
    13. EPA Substance Registry System: 7-CHLORO-1H-INDAZOLE-3-CARBOXYLIC ACID(129295-32-5)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 129295-32-5(Hazardous Substances Data)

129295-32-5 Usage

Uses

Since the provided materials do not specify any particular applications for 7-CHLORO-1H-INDAZOLE-3-CARBOXYLIC ACID, it is not possible to list its uses based on the given information. However, as a chemical compound, it may have potential applications in various industries such as pharmaceuticals, materials science, or chemical research, depending on its properties and further modification. Further research and development would be required to explore and confirm its potential uses.

Check Digit Verification of cas no

The CAS Registry Mumber 129295-32-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,9,2,9 and 5 respectively; the second part has 2 digits, 3 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 129295-32:
(8*1)+(7*2)+(6*9)+(5*2)+(4*9)+(3*5)+(2*3)+(1*2)=145
145 % 10 = 5
So 129295-32-5 is a valid CAS Registry Number.
InChI:InChI=1/C8H5ClN2O2/c9-5-3-1-2-4-6(5)10-11-7(4)8(12)13/h1-3H,(H,10,11)(H,12,13)

129295-32-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 7-Chloro-1H-indazole-3-carboxylic acid

1.2 Other means of identification

Product number -
Other names 7-chloro-2H-indazole-3-carboxylic acid

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:129295-32-5 SDS

129295-32-5Upstream product

129295-32-5Downstream Products

129295-32-5Relevant articles and documents

Development of potent serotonin-3 (5-HT3) receptor antagonists. II. Structure-activity relationships of N-(1-benzyl-4-methylhexahydro-1H-1,4- diazepin-6-yl)carboxamides

Harada,Morie,Hirokawa,Terauchi,Fujiwara,Yoshida,Kato

, p. 1912 - 1930 (2007/10/03)

Our studies on 4-amino-5-chloro-2-ethoxybenzamides led to the discovery that the N-(1,4-dimethylhexahydro-1H-1,4-diazepin-6-yl)benzamide 9 and the 1- benzyl-4-methylhexahydro-1H-1,4-diazepine analogue 10 are potent serotonin-3 (5-HT3) receptor antagonists. Structure-activity relationship (SAR) studies on the influence of the aromatic nucleus of 9 and 10 upon inhibition of the von Bezold-Jarisch reflex in rats are described. Heteroaromatic rings such as pyrrole, thiophene, furan, pyridine, pyridaziae, 1,2-benzisoxazole, indole, quinoline, and isoquinoline rings showed weak 5-HT3 receptor antagonistic activity. Within this series, use of the 1H-indazole ring as an aromatic moiety led to a substantial increase of the activity; the 1H- indazolylcarboxamides 54, 57, 97, and 102 showed potent 5-HT3 receptor antagonistic activity. The optimal compound identified via extensive SAR studies was N-(1-benzyl-4-methylhexahydro-1H-1,4-diazepin-6-yl)-1H-indazole- 3-carboxamide (54), whose effect was superior to that of the corresponding benzamide 10 and essentially equipotent to those of ondansetron (1) and granisetron (4).

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