129295-49-4

Upstream product

• 129295-40-5 1-benzyl-6-hydroxymethyl-4-methyl-6-nitrohexahydro-1H-1,4-diazepine 
• 129295-41-6 1-benzyl-4-methyl-6-nitrohexahydro-1H-1,4-diazepine 
• 129295-44-9 6-benzenesulfonylamino-1-benzyl-4-methylhexahydro-1H-1,4-diazepine 
• 146759-95-7 N-(1-benzyl-4-methylhexahydro-1H-1,4-diazepine-6-yl)benzamide 
• 166047-30-9 1-benzyl-6-(tert-butoxycarbonylamino)-4-methylhexahydro-1H-1,4-diazepine 
• 166047-36-5 6-amino-1-benzyl-4-methyl-7-oxohexahydro-1H-1,4-diazepine 

Downstream Products

• 172092-46-5 4-amino-N-(1-benzyl-4-methylhexahydro-1H-1,4-diazepin-6-yl)-5-chloro-2-hydroxybenzamide 

Relevant academic research and scientific papers

A FACILE SYNTHESIS OF 6-AMINO-1-BENZYL-4-METHYL- AND 6-AMINO-1,4-DIMETHYLHEXAHYDRO-1H-1,4-DIAZEPINES, THE AMINE PART OF SUBSTITUTED BENZAMIDES WITH A POTENT SEROTONIN 3 RECEPTOR ANTAGONISTIC ACTIVITY

A facile synthesis of 6-amino-1-benzyl-4-methyl- and 6-amino-1,4-dimethylhexahydro-1H-1,4-diazepines (16a and 16b) which have served as the amine part of the new and novel benzamides (3 and 4) with a potent serotonin 3 receptor antagonistic activity is re

Synthesis of 6-amino-1-benzyl-4-methylhexahydro-1H-1,4-diazepine

Five variants (methods A-E) of a synthetic route to 6-amino-1-benzyl-4-methylhexahydro-1H-1,4-diazepine (3b) using N-benzyl-N'-methylethylenediamine (8a) are described. The reaction of 8a with 1 benzenesulfonyl-2-bromomethylaziridine (7), 2-phenyl-4-(p-to