129297-33-2Relevant academic research and scientific papers
An easy synthesis of α-trifluoromethyl-amines from aldehydes or ketones using the Ruppert-Prakash reagent
Radchenko, Dmytro S.,Michurin, Oleg M.,Chernykh, Anton V.,Lukin, Oleg,Mykhailiuk, Pavel K.
supporting information, p. 1897 - 1898 (2013/04/24)
A small library of structurally diverse primary amines bearing a geminal CF3 group was synthesized on a preparative scale. The synthesis starts with an aldehyde or ketone that reacts with benzylamine yielding the corresponding imine. The latter is then trifluoromethylated with Me 3SiCF3 under acidic conditions to give a benzylalkylamine. In the last step the Pd-mediated hydrogenation of the benzylalkylamines furnishes the title compounds. All synthetic steps are high-yielding; neither the isolation of the intermediates nor the chromatographic purification of the products is necessary.
Reaction of Schiff bases obtained from methyl cyclopropyl ketone with acyl chlorides
Minbaev, B. U.,Mataeva, S. O.,Shostakovskii, V. M.
, p. 466 - 469 (2007/10/02)
The acylation of Schiff compounds obtained from methyl cyclopropyl ketone by acyl chlorides in the presence of hydrogen chloride acceptor provides a convenient method for the synthesis of N-(1-cyclopropylvinyl)amides.
