129302-14-3Relevant academic research and scientific papers
C-C bond cleavage studies in bipyrazoles: A convenient synthesis of pyrazolo-5-ols
Singh, Shiv P.,Naithani, Rajesh,Aggarwal, Ranjana,Prakash, Om
, p. 611 - 619 (2005)
The treatment of 4-acetoacetyl derivative (3) of the pyrazoles with hydrazines in ethanol/HCl furnished a variety of bipyrazoles (4). However, when the reaction was performed in sodium acetate/acetic acid/ethanol, different hydrazines gave different products. Under these conditions an unexpected C-C bond cleavage was observed thus affording a convenient route for the formation of pyrazolo-5-ols (5 and 6).
