129302-15-4

Upstream product

• 75843-20-8 3-acetyl-4-hydroxy-6-methyl-2H-pyran-2-one thiosemicarbazone 
• 70-11-1 α-bromoacetophenone 
• 771-03-9 3-acetyl-4-hydroxy-6-methyl-2H-pyran-2-one 
• 151504-48-2 4-hydroxy-6-methyl-3-(1-(2-(4-phenylthiazol-2-yl)hydrazono)ethyl)-2H-pyran-2-one 

Downstream Products

• 1351946-48-9 3-methyl-4-(3-methylisoxazol-5-yl)-1-(4-phenylthiazol-2-yl)-1H-pyrazol-5-ol 

Relevant academic research and scientific papers

A facile route for the synthesis of 1-[5-hydroxy-3-methyl-1-(2-thiazolyl)-4-pyrazolyl)-1,3-butanediones from dehydroacetic acid

Thiosemicarbazone (1) of dehydroacetic acid (DHAA) reacts smoothly with α-haloketones to yield corresponding thiazolylhydrazones (2) of DHAA, which on refluxing in EtOH-AcOH rearrange to the title compounds (3).

Synthesis and antimicrobial activities of some isoxazolyl thiazolyl pyrazoles

A series of isoxazolyl thiazolyl pyrazoles 5a-d was synthesized by multi-step process, starting from 3-Acetyl-4-hydroxy-6-methyl-2H-pyran-2-one (dehydroacetic acid, DHAA) 1. DHAA 1 was easily converted to thiosemicarbazone 2 which on reaction with a-βromo