1293287-54-3Relevant articles and documents
Design and synthesis of novel enhanced water soluble hydroxyethyl analogs of combretastatin A-4
Lee, Megan,Brockway, Olivia,Dandavati, Armaan,Tzou, Samuel,Sjoholm, Robert,Nickols, Alexis,Babu, Balaji,Chavda, Sameer,Satam, Vijay,Hartley, Rachel M.,Westbrook, Cara,Mooberry, Susan L.,Fraley, Gregory,Lee, Moses
, p. 2087 - 2091 (2011)
Thirteen hydroxyethyl- analogs of combretastatin A-4 (CA-4) that contain the 1-(1′-hydroxyethyl)-1-(3″,4″,5″-trimethoxyphenyl)-2- (substituted phenyl)ethene framework were synthesized. Molecular modeling studies at the DFT level showed that compound 3j ad
Acetyl analogs of combretastatin A-4: Synthesis and biological studies
Lee, Moses,Babu, Balaji,Lee, Megan,Lee, Lauren,Strobel, Raymond,Brockway, Olivia,Nickols, Alexis,Sjoholm, Robert,Tzou, Samuel,Chavda, Sameer,Desta, Dereje,Fraley, Gregory,Siegfried, Adam,Pennington, William,Hartley, Rachel M.,Westbrook, Cara,Mooberry, Susan L.,Kiakos, Konstantinos,Hartley, John A.
experimental part, p. 2359 - 2367 (2011/05/12)
The combretastatins have received significant attention because of their simple chemical structures, excellent antitumor efficacy and novel antivascular mechanisms of action. Herein, we report the synthesis of 20 novel acetyl analogs of CA-4 (1), synthesi
