1293366-68-3Relevant academic research and scientific papers
Arylation of indoles using cyclohexanones dually-catalyzed by niobic acid and palladium-on-carbons
Ban, Kazuho,Sajiki, Hironao,Sawama, Yoshinari,Yamamoto, Yuta
, p. 3898 - 3902 (2020)
3-Arylindoles were easily constructed from indoles and cyclohexanone derivatives using a combination of catalytic niobic acid-on-carbon (Nb2O5/C) and palladium-on-carbon (Pd/C) under heating conditions without any oxidants. The Lewis acidic Nb2O5/C promoted the nucleophilic addition of indoles to the cyclohexanones, and the subsequent dehydration and Pd/C-catalyzed dehydrogenation produced the 3-arylindoles. The additive 2,3-dimethyl-1,3-butadiene worked as a hydrogen acceptor to facilitate the dehydrogenation step.
Palladium-catalyzed direct denitrogenative C-3-arylation of 1H-indoles with arylhydrazines using air as the oxidant
Chen, Yongxin,Guo, Shuaibo,Li, Kangning,Qu, Jinpeng,Yuan, Hua,Hua, Qiuru,Chen, Baohua
supporting information, p. 711 - 715 (2013/03/29)
A novel palladium-catalyzed approach to direct C-3-arylation of 1H-indoles with arylhydrazines using air as the oxidant via C-N bond cleavage has been developed. Various substituents are tolerated in this system in moderate to good yields. This reaction could also be compatible with a larger scale. Thus, this strategy using arylhydrazines as arylating reagents provides a powerful method for constructing substituted 3-aryl-1H-indoles. Copyright
Metal-free direct arylations of indoles and pyrroles with diaryliodonium salts
Ackermann, Lutz,Dellacqua, Monica,Fenner, Sabine,Vicente, Ruben,Sandmann, Rene
supporting information; experimental part, p. 2358 - 2360 (2011/06/25)
Chemical equations presented. Direct arylations of indoles and pyrroles with differently substituted diaryliodonium salts were shown to efficiently proceed in the absence of metal catalysts.
