1293375-06-0Relevant academic research and scientific papers
Synthesis and anti-plasmodial activity of 8β, 13β- Dihydroxypodocarpane derivatives
Young, Ryan M.,Popplewell, Wendy L.,Caira, Mino R.,Van Zyl, Robyn L.,Davies-Coleman, Michael T.
, p. 18 - 23 (2011/05/04)
8β,13β-Dihydroxypodocarpane and eight C-13 substituted derivatives were prepared from the precursor 8bhydroxy-13-podocarpanone synthesised from the naturally occurring diterpene (+)-manool. The synthetic compounds exhibited a range of anti-plasmodial activities (IC50 1-29 μM) and only induced minimal haemolysis of erythrocytes at concentrations 50 and 100 μM. No changes in the morphology of erythrocytes were detected at sub-haemolytic concentrations.
