129339-45-3

Upstream product

• 50612-99-2 methyl 2-bromo-2-(4-methoxyphenyl)acetate 
• 88-75-5 2-hydroxynitrobenzene 

Downstream Products

• 129339-18-0 [2-(4-Methoxy-phenyl)-3-thioxo-2,3-dihydro-benzo[1,4]oxazin-4-yl]-acetic acid 
• 244620-32-4 4-(5-Bromo-pentyl)-2-(4-methoxy-phenyl)-4H-benzo[1,4]oxazin-3-one 

Relevant academic research and scientific papers

Phase-transfer-catalysed asymmetric synthesis of 2,2-disubstituted 1,4-benzoxazin-3-ones

1,4-Benzoxazin-3-one is a scaffold which is found in a variety of biologically active molecules. Because of its unique structure and drug-like activities, 1,4-benzoxazin-3-ones have been widely used in drug discovery. However, just a few methods have been developed to access these molecules by catalytic asymmetric synthesis. We report herein the phase-transfer-catalysed asymmetric alkylation of 2-aryl-1,4-benzoxazin-3-ones as a new way for the highly enantioselective synthesis of 2,2-disubstituted 1,4-benzoxazin-3-ones.

Benzoxazinoes/benzothiazinones as serine protease inhibitors

This invention discloses benzoxazinone and benzothiazinone compounds which display inhibitory effects on serine proteases such as factor Xa, thrombin, and/or factor VIIa. The invention also discloses pharmaceutically acceptable salts of the compounds, pharmaceutically acceptable compositions comprising the compounds or their salts, and methods of using them as therapeutic agents for treating or preventing disease states in mammals characterized by abnornal thrombosis.