129339-77-1

Upstream product

• 21852-32-4 4-bromomethyl-1,2-dimethoxybenzene 
• 725724-47-0 (R)-2-(3,4-Dimethoxy-benzyl)-1,4-bis-((4S,5R)-3,4-dimethyl-2-oxo-5-phenyl-imidazolidin-1-yl)-butane-1,4-dione 
• 65859-97-4 veratrylidenesuccinic acid 
• 65859-88-3 (3,4-dimethoxybenzylidene)succinic acid 

Downstream Products

• 129339-87-3 (R)-2-(3,4-Dimethoxy-benzyl)-butane-1,4-diol 
• 108102-77-8 (R)-4-(3,4-dimethoxybenzyl)dihydrofuran-2(3H)-one 
• 97024-95-8 (R)-3-(3,4-Dimethoxy-benzyl)-dihydro-furan-2-one 
• 725724-50-5 (R)-3-(3,4-Dimethoxy-benzyl)-dihydro-furan-2,5-dione 

Relevant academic research and scientific papers

Highly diastereoselective alkylation of vicinal dianions of chiral succinic acid derivatives: A new general strategy to (R)-β-arylmethyl-γ- butyrolactones

The vicinal dianions derived from chiral succinic acid derivatives, 1,4-bis[(4R,5S)-3,4-dimethyl-2-oxo-5-phenylimidazolidin-1-yl]butane-1,4-dione and 1,4-bis[(4S,5R)-3,4-dimethyl-2-oxo-5-phenylimidazolidin-1-yl]butane-1,4- dione react with arylmethyl bromides with high diastereo- and regio-selectivity to provide the corresponding chiral α-arylmethylated succinic acid derivatives; the (R)-products are converted into (R)-β-arylmethyl-γ- butyrolactones and (R)-α-arylmethyl-γ-butyrolactones.

Asymmetric Synthesis of (R)- and (S)-4-(Substituted Benzyl)dihydrofuran-2(3H)-ones: An Application of the Ruthenium-binap Complex-catalysed Asymmetric Hydrogenation of Alkylidenesuccinic Acids

A concise synthesis of (S)- or (R)-4-(substituted benzyl)dihydrofuran-2(3H)-ones (1) with high enantiomeric purity is presented. (S)- or (R)-(Substituted benzyl)succinic acids (6) 97percent enantiomeric excess) were first prepared by Ru2Cl4(R)- or (S

RUTHENIUM(II)-BINAP COMPLEX CATALYZED ASYMMETRIC HYDROGENATION OF UNSATURATED DICARBOXYLIC ACIDS

Asymmetric hydrogenation of unsaturated dicarboxylic acids employing ruthenium-BINAP complexes as catalyst gave optically active 2-alkylsuccinic acids with high enantioselectivities.