1293395-67-1 Usage
Biochem/physiol Actions
PF-5006739 is a potent inhibitor of casein kinases 1 delta (CK1δ) and 1 epsilon (CK1ε), key regulators of the suprachiasmatic nucleus (SCN) central clock and also linked to the development of drug addiction through PERIOD proteins (PER1–3) and dopamine- and cAMP-regulated neuronal phosphoprotein (DARPP-32) modulation. PF-5006739 has low nM in vitro potency for CK1δ/ε (IC50 values of 3.9 nM for CK1δ and 17.0 nM for CK1ε) and high kinome selectivity. PF-5006739 induced profound phase delays in circadian periodicity in both nocturnal and diurnal animal models and attenuated opioid drug-seeking behavior in a rodent operant reinstatement model.
Check Digit Verification of cas no
The CAS Registry Mumber 1293395-67-1 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,9,3,3,9 and 5 respectively; the second part has 2 digits, 6 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 1293395-67:
(9*1)+(8*2)+(7*9)+(6*3)+(5*3)+(4*9)+(3*5)+(2*6)+(1*7)=191
191 % 10 = 1
So 1293395-67-1 is a valid CAS Registry Number.
1293395-67-1Relevant academic research and scientific papers
Novel Compounds As Casein Kinase Inhibitors
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Page/Page column 20-21, (2011/05/05)
Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.
