1293914-39-2Relevant academic research and scientific papers
Synthesis of (3S,4R)-bengamide e
Liu, Qi Jun,Li, Hong,Chen, Shao Peng,Zhou, Guo Chun
, p. 505 - 507 (2012/01/05)
(3S,4R)-Bengamide E (2) was synthesized starting from d-glucono-δ- lactone (3) and the key deoxygenation step from 13 to 15 was achieved by the application of NaBH3CN and ZnI2. Compared with natural bengamide E (1), the synthetic compound (3S,4R)-bengamide E (2) was inactive against the cell growth of HUVEC and cancer cells. These data represent the significance of the stereochemistry at C-3 and C-4 of bengamides for structural recognition and binding with the target(s).
