129396-80-1

Upstream product

• 98105-42-1 (S)-2-(t-butoxycarbonylamino)-3-cyclohexyl-1-propanal 
• 121079-58-1 ((S)-1-Cyclohexylmethyl-2-hydroxy-4-methyl-pent-3-enyl)-carbamic acid tert-butyl ester 
• 121079-59-2 (S)-4-Cyclohexylmethyl-2,2-dimethyl-5-(2-methyl-propenyl)-oxazolidine-3-carboxylic acid tert-butyl ester 
• 35059-50-8 t-butyl diazoacetate 

Downstream Products

• 121079-62-7 (1S,3S)-3-((1S,2S)-2-tert-Butoxycarbonylamino-3-cyclohexyl-1-hydroxy-propyl)-2,2-dimethyl-cyclopropanecarboxylic acid 
• 121154-23-2 (1R,3R)-3-((1S,2S)-2-tert-Butoxycarbonylamino-3-cyclohexyl-1-hydroxy-propyl)-2,2-dimethyl-cyclopropanecarboxylic acid 
• 129446-03-3 (1S,3S)-3-((1S,2S)-2-Amino-3-cyclohexyl-1-hydroxy-propyl)-2,2-dimethyl-cyclopropanecarboxylic acid; compound with trifluoro-acetic acid 
• 129518-43-0 (1R,3R)-3-((1S,2S)-2-Amino-3-cyclohexyl-1-hydroxy-propyl)-2,2-dimethyl-cyclopropanecarboxylic acid; compound with trifluoro-acetic acid 
• 129396-81-2 (1R,3R)-3-((1S,2S)-2-tert-Butoxycarbonylamino-3-cyclohexyl-1-hydroxy-propyl)-2,2-dimethyl-cyclopropanecarboxylic acid tert-butyl ester 
• 129446-02-2 (1S,3S)-3-((1S,2S)-2-tert-Butoxycarbonylamino-3-cyclohexyl-1-hydroxy-propyl)-2,2-dimethyl-cyclopropanecarboxylic acid tert-butyl ester 

Relevant academic research and scientific papers

Conformationally restricted P1-P1' transition analogues. Synthesis of 1(R), 3(R) [1(S), 2(S)] and 1(S), 3(S) [1(S),2(S)] 3-[3-cyclohexyl-2-[(BOC)amino]-1-hydroxypropyl]-2,2-dimethylcycloprop ane carboxylic acids

A concise synthesis and determination of absolute stereochemistry of two novel diastereomeric cyclopropyl containing transition state mimics is described.