129409-54-7

Basic information

• Product Name: ethyl 2-(2,4-difluorophenyl)acetate
• Synonyms: ethyl 2-(2,4-difluorophenyl)acetate;Ethyl 2-(2,4-Difluorophenyl)Acetate(WXC01400)
• CAS NO: 129409-54-7
• Molecular Formula: C₁₀H₁₀F₂O₂
• Molecular Weight: 200.1820064
• Mol File: 129409-54-7.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: ethyl 2-(2,4-difluorophenyl)acetate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 2-(2,4-difluorophenyl)acetate(129409-54-7)
• EPA Substance Registry System: ethyl 2-(2,4-difluorophenyl)acetate(129409-54-7)

Safety Data

• Hazardous Substances Data: 129409-54-7(Hazardous Substances Data)

Upstream product

• 129409-52-5 ethyl α-bromo-2,4-difluorophenylacetate 
• 64-17-5 ethanol 
• 81228-09-3 2,4-difluorophenylacetic acid 

Downstream Products

• 129409-52-5 ethyl α-bromo-2,4-difluorophenylacetate 
• 157372-95-7 ethyl 2-(2,4-difluorophenyl)-2-oxoacetate 
• 1588424-03-6 7-chloro-3-(2,4-difluorophenyl)-1-ethyl-1,6-naphthyridin-2(1H)-one 
• 894789-39-0 C₁₀H₉F₂NO₃ 
• 129430-60-0 meso-diethyl 2,3-bis(2,4-difluorophenyl)succinate 

Relevant articles and documents

2-(Halogenated Phenyl) acetamides and propanamides as potent TRPV1 antagonists

A series consisting of 117 2-(halogenated phenyl) acetamide and propanamide analogs were investigated as TRPV1 antagonists. The structure–activity analysis targeting their three pharmacophoric regions indicated that halogenated phenyl A-region analogs exhibited a broad functional profile ranging from agonism to antagonism. Among the compounds, antagonists 28 and 92 exhibited potent antagonism toward capsaicin for hTRPV1 with Ki[CAP] = 2.6 and 6.9 nM, respectively. Further, antagonist 92 displayed promising analgesic activity in vivo in both phases of the formalin mouse pain model. A molecular modeling study of 92 indicated that the two fluoro groups in the A-region made hydrophobic interactions with the receptor.

MULTIPLE KINASE PATHWAY INHIBITORS

Kinase with inhibitory activity against kinases disposed in multiple signaling pathways and their therapeutic uses.

Process for the preparation of fluorophenylalkylene acid derivatives

The invention relates to the preparation of fluorophenylalkylene acid derivatives of the formulae (4-1)-(4-3): by reaction between fluoroarylmetal halides of formulae (1-1) or (1-2) with carboxylic acid derivatives of formulae (2-1)-(2-3): in the presence