129411-66-1Relevant articles and documents
Selective α-glucosidase substrates and inhibitors containing short aromatic peptidyl moieties
Park, Sangeun,Hyun, Soonsil,Yu, Jaehoon
supporting information; experimental part, p. 2441 - 2444 (2011/06/17)
We constructed a library of sugar-dipeptide conjugate to find out the best complementary against hydrophobic pocket of α-glucosidase. The best substrate showed 150-fold improved Km value relative p-acetaminophenyl-α-d-glucopyranoside for α-glucosidase from Bacillus stearothermophillus. Using information from the complementary, we synthesized sp-WY and β-Glc-sp-WY, which selectivity inhibited the cognate enzyme.