129423-12-7

Basic information

• Product Name: 2,3-epoxypropyl-5-nitrofuran-2-carboxylate
• Synonyms: 2,3-epoxypropyl-5-nitrofuran-2-carboxylate
• CAS NO: 129423-12-7
• Molecular Formula: C8H7 N O6
• Molecular Weight: 0
• Mol File: 129423-12-7.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 370.3°C at 760 mmHg
• Flash Point: 177.8°C
• Appearance: /
• Density: 1.498g/cm³
• Vapor Pressure: 1.12E-05mmHg at 25°C
• Refractive Index: 1.555
• CAS DataBase Reference: 2,3-epoxypropyl-5-nitrofuran-2-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3-epoxypropyl-5-nitrofuran-2-carboxylate(129423-12-7)
• EPA Substance Registry System: 2,3-epoxypropyl-5-nitrofuran-2-carboxylate(129423-12-7)

Safety Data

• Hazardous Substances Data: 129423-12-7(Hazardous Substances Data)

Usage

InChI:InChI=1/C8H7NO6/c10-8(14-4-5-3-13-5)6-1-2-7(15-6)9(11)12/h1-2,5H,3-4H2

Upstream product

• 25084-14-4 5-nitrofuran-2-carboxylic chloride 
• 73486-42-7 allyl ester of 5-nitrofuran-2-carboxylic acid 

Relevant articles and documents

Synthesis and Evaluation of Novel Electrophilic Nitrofuran Carboxamides and Carboxylates as Radiosensitizers and Bioreductively Activated Cytotoxins

A series of 5-nitrofuran-2- and 3-carboxamides bearing alkylating side-chains has been synthesized and tested for their ability to radiosensitize selectively hypoxic Chinese hamster cells (V79) to the lethal effects of ionizing radiation and also for their ability to act directly and selectively as cytotoxic drugs on hypoxic V79 cells.The compounds were extremly efficient radiosensitizers of such cells in vitro and were more efficient than known nitroimidazoles of similar type.Their efficiencies as radiosensitizers correlated with their high electron affinity(E17) as measured by pulse-radiolysis.However the compounds showed little radiosensitizing activity towards KHT sarcomas in C3H mice.The compounds in this series of nitrofurans were generally more toxic towards hypoxic cells than towards oxic cells in vitro but were less effective upon the basis of a differential effect than were similar nitroimidazoles reported previously.