129425-32-7

Basic information

• Product Name: 1-(3-bromo-1-propynyl)-2-chlorobenzene
• Synonyms: 1-(3-bromo-1-propynyl)-2-chlorobenzene
• CAS NO: 129425-32-7
• Molecular Weight: 229.504
• Mol File: 129425-32-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-(3-bromo-1-propynyl)-2-chlorobenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3-bromo-1-propynyl)-2-chlorobenzene(129425-32-7)
• EPA Substance Registry System: 1-(3-bromo-1-propynyl)-2-chlorobenzene(129425-32-7)

Safety Data

• Hazardous Substances Data: 129425-32-7(Hazardous Substances Data)

Upstream product

• 615-41-8 2-iodochlorobenzene 
• 80151-26-4 3-(2-chlorophenyl)-prop-2-yn-1-ol 

Relevant articles and documents

Novel 5-(3-aryl-2-propynyl)-5-(arylsulfonyl)thiazolidine-2,4-diones as antihyperglycemic agents

Novel 5-(3-aryl-2-propynyl)-5-(arylsulfonyl)thiazolidine-2,4-diones and 5-(3-aryl-2-propynyl)5-(arylsulfanyl)thiazolidine-2,4-diones were prepared and evaluated as oral antihyperglycemic agents in the obese, insulin resistant db/db mouse model at 100 mg/kg and, if the analogue had sufficient potency, 20 mg/kg. The sulfonylthiazolidinediones, 2, were more potent than the corresponding sulfanylthiazolidinedione congeners, 1. With regard to substituent effects on the 3-propynyl phenyl ring (Ar') of 2, 4-halogen substitution generally resulted in the more potent analogues. Substituent effects on the phenylsulfonyl moiety (Ar) of 2 were less clear, although para-halogen substitution on Ar generally was preferable. 2-Pyridinesulfonyl derivatives (Ar = 2-pyridine in 2) also had good potency. Several compounds from series 2 were effective at lowering glucose and insulin in the obese, insulin resistant ob/ob mouse at the 50 mg/kg oral dose. Compound 20 significantly improved the glucose tolerance of obese, insulin resistant Zucker rats at the 20 mg/kg dose level and had no effect on plasma glucose or on glucose tolerance in normal rats fasted for 18 h at the 100 mg/kg level.