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129430-93-9

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129430-93-9 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 129430-93-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,9,4,3 and 0 respectively; the second part has 2 digits, 9 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 129430-93:
(8*1)+(7*2)+(6*9)+(5*4)+(4*3)+(3*0)+(2*9)+(1*3)=129
129 % 10 = 9
So 129430-93-9 is a valid CAS Registry Number.
InChI:InChI=1/C25H25NO3/c1-29-24(28)23-17-22(27)18-26(23)25(19-11-5-2-6-12-19,20-13-7-3-8-14-20)21-15-9-4-10-16-21/h2-16,22-23,27H,17-18H2,1H3/t22-,23+/m1/s1

129430-93-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name TRANS-4-HYDROXY-N-TRIPHENYLMETHYL-L-PROLINE METHYL ESTER

1.2 Other means of identification

Product number -
Other names methyl (2S,4R)-4-hydroxy-1-tritylpyrrolidine-2-carboxylate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:129430-93-9 SDS

129430-93-9Relevant articles and documents

Enantioselective synthesis and physicochemical properties of libraries of 3-amino- and 3-amidofluoropiperidines

Orliac, Aurelie,Routier, Julie,Burgat Charvillon, Fabienne,Sauer, Wolfgang H. B.,Bombrun, Agnes,Kulkarni, Santosh S.,Gomez Pardo, Domingo,Cossy, Janine

, p. 3813 - 3824 (2014/04/03)

The enantioselective syntheses of 3-amino-5-fluoropiperidines and 3-amino-5,5-difluoropiperidines were developed using the ring enlargement of prolinols to access libraries of 3-amino- and 3-amidofluoropiperidines. The study of the physicochemical properties revealed that fluorine atom(s) decrease(s) the pKa and modulate(s) the lipophilicity of 3-aminopiperidines. The relative stereochemistry of the fluorine atoms with the amino groups at C3 on the piperidine core has a small effect on the pK a due to conformationnal modifications induced by fluorine atom(s). In the protonated forms, the C-F bond is in an axial position due to a dipole-dipole interaction between the N-H+ and C-F bonds. Predictions of the physicochemical properties using common software appeared to be limited to determine correct values of pKa and/or differences of pK a between cis- and trans-3-amino-5-fluoropiperidines.

The synthesis and biological activity of C2-fluorinated pyrrolo[2,1-c][1,4]benzodiazepines

O'Neil, Ian A.,Thompson, Stephen,Kalindjian, S. Barret,Jenkins, Terence C.

, p. 7809 - 7812 (2007/10/03)

The novel C2-fluorinated pyrrolobenzodiazepines (1, 2 and 3) have been prepared from commercially available trans-hydroxyproline in good overall yield and were screened for in vitro cytotoxicity against a number of cancer cell lines. The 2R-fluoro isomer 2 exhibits an activity of 76 nM against the CH1 cell line.

Simple Synthesis of cis-4-Hydroxy-L-proline and Derivatives Suitable for Use as Intermediates in Peptide Synthesis

Papaioannou, Dionissios,Stavropoulos, George,Karagiannis, Kostas,Francis, George W.,Brekke, Trond,Aksnes, Dagfinn W.

, p. 243 - 251 (2007/10/02)

An intramolecular Mitsunobu reaction in the presence of triphenylphosphine - diethyl azodicarboxylate (TPP-DEAD) resulted in the conversion of trans-4-hydroxy-N-trityl-L-proline to 5-triphenylmethyl-2-oxa-5-aza-bicycloheptan-3-one.This bicyclic lactone proved to be a key intermediate in the synthesis of cis-4-hydroxy-L-proline and derivatives thereof.TPP-DEAD-catalysed methanolysis of the key lactone gave the methyl ester of cis-4-hydroxy-N-trityl-L-proline, while ammonolysis in isopropyl alcohol provided the corresponding amide. p-Toluene-sulfonic acid treatmen t of the lactone, ester and amide led to detritylation and formation of the corresponding p-toluenesulfonates.Saponification of the key intermediate provided cis-4-hydroxy-N-trityl-L-proline which was first benzylated and then elaborated to the 1-hydroxybenzotriazolyl ester.This last ester and the three p-tolenesulfonates preparared above were utilised for the incorporation of cis-4-hydroxy-L-proline in the synthesis of model peptides.

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