129446-51-1Relevant academic research and scientific papers
CARBOXYMETHYLOXIMATION OF KETO SUBSTRATES. A USEFUL GRAFTING PROCEDURE APPLIED ON VIRGINAMYCIN FACTORS A et B.
Anteunis, M. J. O.,Callens, R.,Sharma, N. K.
, p. 209 - 218 (2007/10/02)
Virginamycins M1 and S1 (factors A et B) were converted to their corresponding carboxymethyl oximes 1 et 2 in quantitative yields. 1 was further conjugated with tryptophan methyl ester to obtain derivative 3 in high yield by using BOP-Cl as coupling reagent.The compounds 1, 2 et 3 were fully characterized by I.R. and 1H NMR spectra.Carboxymethyloximation seems to be a practical strategy for the preparation of conjugates of biologically active ketonic substrates.
