1294505-63-7

Basic information

• Product Name: (S)-1-tert-butyl 2-((R)-1-phenylprop-2-yn-1-yl)-pyrrolidine-1,2-dicarboxylate
• Synonyms: (S)-1-tert-butyl 2-((R)-1-phenylprop-2-yn-1-yl)-pyrrolidine-1,2-dicarboxylate
• CAS NO: 1294505-63-7
• Molecular Weight: 329.396
• Mol File: 1294505-63-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (S)-1-tert-butyl 2-((R)-1-phenylprop-2-yn-1-yl)-pyrrolidine-1,2-dicarboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-1-tert-butyl 2-((R)-1-phenylprop-2-yn-1-yl)-pyrrolidine-1,2-dicarboxylate(1294505-63-7)
• EPA Substance Registry System: (S)-1-tert-butyl 2-((R)-1-phenylprop-2-yn-1-yl)-pyrrolidine-1,2-dicarboxylate(1294505-63-7)

Safety Data

• Hazardous Substances Data: 1294505-63-7(Hazardous Substances Data)

Upstream product

• 4187-87-5 (R)-1-phenyl-2-propyn-1-ol 
• 15761-39-4 N-tert-butoxycarbonyl-proline 

Downstream Products

• 15761-39-4 1-(tert-butoxycarbonyl)-L-proline 
• 220510-58-7 tert-butyl (S)-2-(phenylcarbamoyl)pyrrolidine-1-carboxylate 

Relevant articles and documents

Resolution of carboxylic acids using copper(I)-promoted removal of propargylic esters under neutral conditions

A method for the optical resolution of carboxylic acids is described. Condensation of racemic carboxylic acids with chiral terminal propargyl alcohols gave separable diastereomeric esters. Chromatographic separation followed by heating the individual diastereomers in methanol with catalytic copper(I) halide regenerated the carboxylic acids in good yields and in enantiomeric ratios of ?94%. This method is particularly useful for the resolution of carboxylic acids that are incompatible with conventional ester hydrolysis.