129451-35-0Relevant academic research and scientific papers
Studies on Reactions of Nucleoside H-Phosphonates with Bifunctional Reagents. Part 2. Stability of Nucleoside H-Phosphonate Diesters in the Presence of Amino Alcohols
Sobkowski, Michal,Stawinski, Jacek,Sobkowska, Anna,Kraszewski, Adam
, p. 1803 - 1808 (2007/10/02)
H-Phosphonate diesters undergo transesterification with amino alcohols to afford as primary products the mixed and symmetrical H-phosphonate esters.Alcohols react similarly but only in the presence of an external base or in basic solvent.The rate and the course of transesterification strongly depend on the reaction conditions, the reactivity of the H-phosphonate diester used, and the nature of the amino alcohol.
ONE STEP INTRODUCTION OF THE ACTIVATED CARBOXYL GROUPS WITH LONG ALIPHATIC ARM ONTO HYDROXYL GROUPS CONTAINING POLYMERS
Arnold, Lubos,Smrt, Jiri
, p. 1321 - 1325 (2007/10/02)
Bis-N-hydroxysuccinimide ester of 1,10-decanediol bis-succinate (Ia) react with hydroxyl groups bearing polymers (Spheron, cellulose, Sephacryl) affording activated carboxyl group containing derivatives IIa.Analogous 4-nitrophenyl group bearing Spheron derivative IIb was prepared starting from bis-4-nitrophenyl ester of 1,10-decanediol bis-succinate (Ib). 3'-O-(4,4'-dimethoxytriphenylmethyl)-2'-deoxythimidine 5'-(6-amino-1-hexyl)-phosphate (V) was developed as reagent to determine the extent of activated carboxyl groups.Attachment ranging from 3.1 - 7.3 μmol/g was achieved.
