129451-62-3

Upstream product

• 1071-73-4 5-Hydroxy-2-pentanone 
• 98-59-9 p-toluenesulfonyl chloride 
• 16297-94-2 3-(3-Methyldiazirin-3-yl)propan-1-ol 

Downstream Products

• 1337883-32-5 C₁₂H₂₃N₅O₃ 

Relevant academic research and scientific papers

MUTANT VIRUS, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF

The present invention relates to a mutated virus. Said virus can be an influenza virus of human or other animal origin. The present invention also relates to a method for preparing the mutated virus, the method comprising introducing UAG codons into positions upstream of the stop codons per se of one or more genes of a viral genome by reverse genetic techniques. The present invention further relates to uses of the mutated virus, for example, as a live attenuated vaccine, or in replication of controllable and safe virus models, and the like.

Photoaffinity palladium reagents for capture of protein-protein interactions

Protein-protein interactions (PPIs) are indispensable in almost all cellular processes. Probing of complex PPIs provides new insights into the biological system of interest and paves the way for the development of therapeutics. Herein, we report a strategy for the capture of protein-protein interactions using photoaffinity palladium reagents. First, the palladium-mediated reagent site specifically transferred a photoaffinity modified aryl group to the designated cysteine residue. Next, the photoaffinity group was activated by UV radiation to trap the proximal protein residue for the formation of a crosslink. This strategy was used to capture the PYL-ABA-PP2C interaction, which is at the core of the abscisic acid (ABA) signalling pathway. Our results indicated that this palladium-mediated strategy can serve as an alternative for incorporating an increasing number of diverse substrates for protein crosslinking through cysteine modifications and can be explored for use in mapping protein-peptide or protein-protein interaction surfaces and in trapping potential interacting partners.

Triterpene derivative and application thereof in resistance to Ebola virus

The invention relates to a use of a triterpene derivative shown in a formula in preparation of a medicine used for preventing or treating an Ebola disease. The triterpene derivative has obvious inhibitory effect on the Ebola virus, can obviously inhibit the Ebola virus from entering a cell and can be used for preventing or treating Ebola. The invention also provides a new triterpene compound which can inhibit the Ebola virus. (The formula is described in the specification.).