3'-TBDMS-Bz-rA Phosphoramidite is a nucleotide and adenosine derivative that plays a crucial role in the synthesis of specific adenosine-inosine monophosphate (cAIMP) analogs. These analogs are known to activate the stimulator of interferon genes (STING), which is involved in the immune response against various pathogens and cancer cells.
129451-75-8
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Basic information
- Product Name: 3'-TBDMS-Bz-rA Phosphoramidite
- Synonyms: 3'-TBDMS-Bz-rA Phosphoramidite;N-Benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-3'-O-[(1,1-dimethylethyl)dimethylsilyl]adenosine 2'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite];Adenosine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-3'-O-[(1,1-dimethylethyl)dimethylsilyl]-, 2'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite];Adenosine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-3'-O-[(1,1-dimethyl ethyl)dimethylsilyl]-, 2'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite];(2R,3R,4R,5R)-2-(6-benzamido-9H-purin-9-yl)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite(WXC08717);N6-Benzoyl-3'-O-tert-butyldimethylsilyl-5'-O-DMT-adenosine 2'-CEphosphoramidite;N6-Benzoyl-3'-O-tert-butyldimethylsilyl-adenosine 2'-CE phosphoramidite;(2R,3R,4R,5R)-2-(6-benzamido-9H-purin-9-yl)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylpho
- CAS NO:129451-75-8
- Molecular Formula: C53H66N7O8PSi
- Molecular Weight: 988.192501
- EINECS: 1592732-453-0
- Product Categories: N/A
- Mol File: 129451-75-8.mol
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Chemical Properties
- Melting Point: N/A
- Boiling Point: N/A
- Flash Point: N/A
- Appearance: /
- Density: N/A
- Refractive Index: N/A
- Storage Temp.: 2-8°C
- Solubility: N/A
- PKA: 7.87±0.43(Predicted)
- CAS DataBase Reference: 3'-TBDMS-Bz-rA Phosphoramidite(CAS DataBase Reference)
- NIST Chemistry Reference: 3'-TBDMS-Bz-rA Phosphoramidite(129451-75-8)
- EPA Substance Registry System: 3'-TBDMS-Bz-rA Phosphoramidite(129451-75-8)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany:
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 129451-75-8(Hazardous Substances Data)
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129451-75-8 Usage
Uses
Used in Pharmaceutical Industry:3'-TBDMS-Bz-rA Phosphoramidite is used as a key intermediate for the synthesis of cAIMP analogs, which are essential in the development of novel therapeutic strategies targeting the STING pathway. This application is significant for enhancing the immune response against cancer and infectious diseases.
Used in Research and Development:
In the field of research and development, 3'-TBDMS-Bz-rA Phosphoramidite serves as a valuable compound for studying the structure-activity relationships of cAIMP analogs and their interactions with the STING receptor. This knowledge can be utilized to design more potent and selective STING agonists for various therapeutic applications.
Used in Drug Discovery:
3'-TBDMS-Bz-rA Phosphoramidite is used as a building block in the drug discovery process, particularly for the development of new antiviral, anticancer, and immunomodulatory agents. The compound's ability to modulate the STING pathway makes it a promising candidate for the creation of innovative drugs targeting a wide range of diseases.
Check Digit Verification of cas no
The CAS Registry Mumber 129451-75-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,9,4,5 and 1 respectively; the second part has 2 digits, 7 and 5 respectively.Calculate Digit Verification of CAS Registry Number 129451-75:
(8*1)+(7*2)+(6*9)+(5*4)+(4*5)+(3*1)+(2*7)+(1*5)=138
138 % 10 = 8
So 129451-75-8 is a valid CAS Registry Number.
129451-75-8Upstream product
129451-75-8Downstream Products
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3'-TBDMS-Bz-rA Phosphoramidite
