1294513-85-1

Basic information

• Product Name: C₂₃H₂₄N₄O
• CAS NO: 1294513-85-1
• Molecular Weight: 372.47
• Mol File: 1294513-85-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₃H₂₄N₄O(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₃H₂₄N₄O(1294513-85-1)
• EPA Substance Registry System: C₂₃H₂₄N₄O(1294513-85-1)

Safety Data

• Hazardous Substances Data: 1294513-85-1(Hazardous Substances Data)

Upstream product

• 70315-69-4 3-iodo-5-nitro-1H-indazole 
• 459133-69-8 tert-butyl 3-iodo-5-nitro-1H-indazole-1-carboxylate 
• 5401-94-5 5-nitroindazole 
• 1294514-39-8 C₂₆H₃₀N₄O₄ 

Relevant articles and documents

Optimisation of ITK inhibitors through successive iterative design cycles

Based on a hit cluster of compounds inhibiting interleukin-2 inducible T-cell kinase (ITK) in the submicromolar range a series of ITK inhibitor libraries were synthesized. Through iterative design cycles including kinase crystal structure information, indolylindazole libraries were identified which showed low nanomolar activity in enzymatic and cellular assays. The potential of these novel lead series was confirmed through in vivo tests in an anti-CD3-IL2 mouse model. The intravenous administration of highly potent ITK inhibitor 11o resulted in dose-dependent, efficient suppression of IL-2.