129463-65-6

Upstream product

• 385843-34-5 3',5'-O-bis(triethylsilyl)-N¹-(β-D-2'-deoxyribosyl)-5-methylpyrimidin-2-one 
• 97626-18-1 1-[2-deoxy-3,5-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-β-D-ribofuranosyl]thymine 
• 1053254-87-7 1-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-4-hydrazino-5-methyl-1H-pyrimidin-2-one 
• 883868-32-4 3',5'-bis(O-tert-butyldimethylsilyl)-N¹-(β-D-2'-deoxyribosyl)-5-methyl-pyrimidin-2-one 
• 385843-33-4 3',5'-O-bis(triethylsilyl)-4-(1,2,4-triazolo)thymidine 
• 385843-32-3 3',5'-O-bis(triethylsilyl)thymidine 
• 50-89-5 thymidine 
• 40733-26-4 3',5'-O-di(tert-butyldimethylsilyl)thymidine 
• 80991-40-8 1-((2R,4S,5R)-4-((tert-butyldimethylsilyl)oxy)-5-(((tertbutyldimethylsilyl)oxy)methyl)tetrahydrofuran-2-yl)-5-methyl-4-(1H-1,2,4-triazol-1-yl)pyrimidin-2(1H)-one 

Downstream Products

• 1363821-34-4 C₄₉H₅₄N₅O₁₅P 
• 1363821-31-1 1-[5-O-(4,4'-dimethoxytrityl)-3-O-levulinyl-2-deoxy-β-D-ribofuranosyl]-5-methyl-2-pyrimidinone 
• 125258-59-5 5'-O-(4,4'-dimethoxytrityl)-N¹-(β-D-2'-deoxyribosyl)-5-methylpyrimidin-2-one 

Relevant academic research and scientific papers

Facile synthesis of a fluorescent deoxycytidine analogue suitable for probing the RecA nucleoprotein filament

equation presented We report the synthesis of the fluorescent 2′-deoxycytidine analogue 5-methylpyrimidin-2-one nucleoside, its incorporation at three specified sites in a single 60-nucleotide DNA molecule, and the use of its total and polarized intrinsic

Photosensitization of DNA by 5-methyl-2-pyrimidone deoxyribonucleoside: (6 - 4) photoproduct as a possible trojan horse

A (photo)sensitive subject: Combined agarose gel electrophoresis and photochemical studies show that 5-methyl-2-pyrimidone (see picture), the main chromophore of (6-4) photoproducts, behaves as a DNA photosensitizer. These results raise the question of whether the (6-4) lesions can act as Trojan horses, enhancing cyclobutane pyrimidine dimer (CPD) formation and oxidative damage. Copyright

Synthesis and properties of fluorescent cycloSal nucleotides based on the pyrimidine nucleoside m5K and its 2′,3′-dideoxy analog dm5K

The synthesis of the fluorescent thymidine nucleoside analog 5-methyl-pyrimidin-2-one nucleoside 1 (m5K) and that of its 2′,3′-dideoxy derivative 2 (dm5K) are described. Moreover, the conversion of 1 and 2 into the corresponding 3-methyl-cycloSal- phosphate triesters 11 and 12 or an enzyme-cleavable prodrug 5-acetoxymethylpropionate-cycloSal-phosphate triester 13, and the fluorescence and hydrolysis properties of these new lipophilic triesters are reported. Finally, the suitability of these cycloSal pronucleotides as probes is demonstrated in a cell-extract hydrolysis experiment and a model study for cell uptake. Wiley-VCH Verlag GmbH & Co. KGaA, 2006.