129505-68-6Relevant academic research and scientific papers
Total Synthesis of the Highly N-Methylated Peptide Jahanyne
Ye, Baijun,Jiang, Peng,Zhang, Tingrong,Ding, Yahui,Sun, Yuanjun,Hao, Xin,Li, Lanshu,Wang, Liang,Chen, Yue
, p. 6741 - 6747 (2018)
Total synthesis of jahanyne (1) was achieved from commercially available materials on a 38 mg scale. The Boc-N-Me-L-Val-OH fragment along with the HATU/DIPEA coupling condition was applied to avoid the diketopiperazine side reaction in solution phase synt
Total synthesis and stereochemical reassignment of tasiamide B
Sun, Tiantian,Zhang, Wei,Zong, Chengli,Wang, Peng,Li, Yingxi
experimental part, p. 364 - 374 (2011/03/22)
The first total synthesis of tasiamide B, an octapeptide bearing 4-amino-3-hydroxy-5-phenylpentanoic acid unit isolated from the marine cyanobacteria Symploca sp. is described. A simple and efficient way was found to avoid the pyroglutamylation of Nα-Me-Gln and led to a reassignment of the Nα-Me-L-Phe of tasiamide B to be N α-Me-D-Phe, which was also supported by 1D and 2D NMR. Copyright
