129529-31-3Relevant academic research and scientific papers
Stereoselective synthesis of phosphoryl-substituted phenols
Xiong, Biquan,Li, Mei,Liu, Yanxi,Zhou, Yongbo,Zhao, Changqiu,Goto, Midori,Yin, Shuang-Feng,Han, Li-Biao
supporting information, p. 781 - 794 (2014/04/03)
Copper-catalyzed C-X activation-phosphorylation of aryls bearing different groups has been achieved using P(O)-H compounds as efficient phosphorylation reagents without the assistance of any ligand. Optically active H-phosphinates can also act as good substrates in the reaction, giving the (Sp)-phosphoryl substituted phenolic compounds stereospecifically with retention of configuration at the phosphorus center. Furthermore, it is shown that the migration of phosphorus on O-aryl phosphonates from oxygen to carbon also proceeds stereospecifically to produce the corresponding optically active (Rp)-phosphoryl-substituted phenolic compounds with retention of configuration at phosphorus via treatment with lithium diisopropylamide (LDA). Plausible mechanisms have been proposed for these reactions.
SYNTHESIS AND SUBSTITUENT EFFECT ON 31P NMR CHEMICAL SHIFT OF ORTHO-HYDROXYARYL DIALKYL PHOSPHINE OXIDES
Li, Shusen,Wang, Guoquan
, p. 119 - 129 (2007/10/02)
In this paper, the synthetic methods for the preparation of o-hydroxyaryl dialkyl phosphine oxides (1) are introduced.The title compounds with low bulky substituent are synthesized successfully by the reactions of Grignard reagents with diethyl o-hydroxya
