129540-26-7

Basic information

• Product Name: 2-(2-bromophenyl)-1-pyrroline
• Synonyms: 2-(2-bromophenyl)-1-pyrroline
• CAS NO: 129540-26-7
• Molecular Weight: 224.1
• Mol File: 129540-26-7.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 2-(2-bromophenyl)-1-pyrroline(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-bromophenyl)-1-pyrroline(129540-26-7)
• EPA Substance Registry System: 2-(2-bromophenyl)-1-pyrroline(129540-26-7)

Safety Data

• Hazardous Substances Data: 129540-26-7(Hazardous Substances Data)

Upstream product

• 129540-27-8 5-(2-bromophenyl)-3,4-dihydro-2H-pyrrole hydrochloride 
• 88-12-0 1-ethenyl-2-pyrrolidinone 
• 6091-64-1 2-bromobenzoic acid ethyl ester 

Downstream Products

• 129540-08-5 trans-1,2,3,5,6,10b-hexahydro-6-<4-(methylthio)phenyl>pyrrolo<2,1-a>isoquinoline-10-carbonitrile 
• 129540-07-4 cis-10-bromo-1,2,3,5,6,10b-hexahydro-6-<4-(methylthio)phenyl>pyrrolo<2,1-a>isoquinoline 
• 129540-07-4 trans-10-bromo-1,2,3,5,6,10b-hexahydro-6-<4-(methylthio)phenyl>pyrrolo<2,1-a>isoquinoline 
• 129540-24-5 2-(2-bromophenyl)pyrrolidine 

Relevant articles and documents

A Hofmann Rearrangement-Ring Expansion Cascade for the Synthesis of 1-Pyrrolines: Application to the Synthesis of 2,3-Dihydro-1H-pyrrolo[2,1-a]isoquinolinium Salts

Treatment of cyclobutanecarboxamide with bis(trifluoroacetoxy)iodobenzene, PhI(OCOCF3)2, resulted in the formation of 1-pyrroline via Hofmann rearrangement of the former followed by in situ ring expansion reaction of the cyclobutylamine intermediate. Further elaboration of this methodology to the synthesis of 2,3-dihydro-1H-pyrrolo[2,1-a]isoquinolinium salts has also been described.

(PYRROLIDIN-2-YL)PHENYL DERIVATIVES

The invention relates to (pyrrolidin-2-yl)phenyl derivatives having the general Formula I wherein R1 is (C1-4)alkyl, halo(C1-4)alkyl, (C1-4)alkyloxy, or halo(C1-4)alkyloxy; R2 is H, (C