1295541-53-5

Downstream Products

• 1295541-57-9 dimethyl 2-acetamido-3,4-di-O-benzyl-2-deoxy-β-D-glucopyranosylphosphonate 
• 1295541-59-1 methyl [(dimethylphosphonyl) 2-acetamido-3,4-di-O-benzyl-1,2-dideoxy-β-D-glucopyranosid]uronate 
• 1295541-55-7 dimethyl 2-acetamido-6-acetyl-3,4-di-O-benzyl-2-deoxy-β-D-glucopyranosylphosphonate 

Relevant academic research and scientific papers

Accessing C-1 phosphonylated 2-acylamino uronic acids via 2-nitro-glycals

Two approaches are described for the synthesis of 2-acylamino uronic acid glycosyl phosphonates from readily accessible d-glucal. The first approach that entailed oxidation of the C-6 hydroxyl group followed by phosphonylation of the uronate 2-nitro-glycal, resulted in the formation of the β-l-gulo- configured phosphonate. Reversing the reaction order resulted in the exclusive formation of the β-d-gluco-configured phosphonate. In both cases the thermodynamic 1,2-trans-di-equatorial phosphonylation product is obtained.